Evidence map›Paper›PMID 37434068›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2023

Outcomes of critically ill older adults with COVID-19: a multicentre retrospective cohort study.

Kiyan Heybati, Eric K C Wong, Jennifer Watt, Hanyan Zou, Arthana Chandraraj, Alissa W Zhang, Richard Norman, Katrina Piggott, Sharon E Straus, Barbara Liu and 1 more

Open access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Kiyan HeybatiMayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA.
Eric K C WongLi Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Jennifer WattLi Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Hanyan ZouDivision of Geriatric Medicine, Department of Medicine, Sinai Health and University Health Network, Toronto, ON, Canada.
Arthana ChandrarajDivision of Geriatric Medicine, Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada.
Alissa W ZhangDivision of Geriatric Medicine, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Richard NormanDivision of Geriatric Medicine, Department of Medicine, Sinai Health and University Health Network, Toronto, ON, Canada.
Katrina PiggottDivision of Geriatric Medicine, Department of Medicine, Sinai Health and University Health Network, Toronto, ON, Canada.
Sharon E StrausDivision of Geriatric Medicine, Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada.
Barbara LiuDivision of Geriatric Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Sangeeta MehtaDepartment of Medicine, Sinai Health System, 600 University Ave., Suite 18-216, Toronto, ON, M5G 1X5, Canada. geeta.mehta@sinaihealth.ca.ORCID http://orcid.org/0000-0002-7073-4769
St. Michael's Hospital · CAUniversity Health Network · CASunnybrook Health Science Centre · CAMayo Clinic in Arizona · USSinai Health System · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOlder adults with COVID-19 have a high prevalence of complications and mortality during hospitalization. Given the large proportion of older adults requiring admission to an intensive care unit (ICU), we aimed to describe the management and outcomes of older adults with COVID-19 requiring ICU care and identify predictors of hospital mortality.

methodsWe included consecutive patients ≥ 65 yr of age who were admitted between 11 March 2020 and 30 June 2021 to one of five Toronto (ON, Canada) ICUs with a primary diagnosis of SARS-CoV-2 infection in a retrospective cohort study. Patient characteristics, ICU treatment, and outcomes were recorded. We used multivariable logistic regression to identify predictors of in-hospital mortality.

resultsOf the 273 patients, the median [interquartile range] age was 74 [69-80] yr, 104 (38.1%) were female, and 164 (60.1%) required invasive mechanical ventilation. One hundred and forty-two patients (52.0%) survived their hospital stay. Compared with survivors, nonsurvivors were older (74 [70-82] yr vs 73 [68-78] yr; P = 0.03), and a smaller proportion was female (39/131, 29.8% vs 65/142, 45.8%; P = 0.01). Patients had long hospital (19 [11-35] days) and ICU (9 [5-22] days) stays, with no significant differences in ICU length of stay or duration of invasive mechanical ventilation between the two groups. Higher APACHE II score, increasing age, and the need for organ support were independently associated with higher in-hospital mortality while female sex was associated with lower mortality.

conclusionsOlder critically ill COVID-19 patients had long ICU and hospital stays, and approximately half died in hospital. Further research is needed to identify individuals who will benefit most from an ICU admission and to evaluate posthospitalization outcomes.

Indexed as

COVID-19AgedCritical IllnessFemaleHospitalizationHospital MortalityHumansIntensive Care UnitsMaleRetrospective StudiesSARS-CoV-2agingCOVID-19critical illnessepidemiologygeriatrics

Identifiers

PMID37434068
OpenAlexW4383894618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.