ArticleInfection2024
Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP).
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Article in Infection, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2.Brain, behavior, & immunity - health · 2026Article
- Post-COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization.Annals of clinical and translational neurology · 2026Article
- Occurrence and clinical correlates of SARS-CoV-2 viremia in two German patient cohorts.Emerging microbes & infections · 2025Article
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Authors and funding
83 authors.
Fridolin Steinbeis *Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Charlotte Thibeault *Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Sarah SteinbrecherDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Yvonne AhlgrimmBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Ira An HaackBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Dietrich AugustDivision of Infectious Diseases, Department of Medicine II, Faculty of Medicine, Medical Centre-University of Freiburg, Freiburg, Germany.
Beate BalzuweitDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Carla BellinghausenDepartment of Respiratory Medicine/Allergology, Medical Clinic 1, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.
Sarah BergerDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Irina Chaplinskaya-SobolDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Oliver CornelyFaculty of Medicine, Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Patrick DoeblinDeutsches Herzzentrum der Charité, Klinik für Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany.
Matthias EndresDepartment of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Claudia FinkBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Carsten FinkeDepartment of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sandra FrankDepartment of Anesthesiology, University Hospital of Ludwig-Maximilians-University (LMU), Munich, Germany.
Sabine HanßDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Tim HartungDepartment of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Johannes Christian HellmuthDepartment of Medicine III, University Hospital of Ludwig-Maximilians-University (LMU), Munich, Germany.
Susanne HeroldDepartment of Medicine V, Internal Medicine, Infectious Diseases and Infection Control, University Hospital Giessen and Marburg, Giessen, Germany.
Peter HeuschmannInstitute of Clinical Epidemiology and Biometry, University Würzburg, Würzburg, Germany.
Jan HeyckendorfDepartment of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
Ralf HeyderCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NUM Coordination Office, Berlin, Germany.
Stefan HippenstielDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Wolfgang HoffmannInstitute for Community Medicine Section Health Care Epidemiology and Community Health, University Medicine Greifswald, Greifswald, Germany.
Sebastian Ulrich KelleDeutsches Herzzentrum der Charité, Klinik für Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany.
Philipp KnapeDeutsches Herzzentrum der Charité, Klinik für Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany.
Philipp KoehlerFaculty of Medicine, Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Lucie KretzlerBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
David Manuel LeistnerDepartment of Cardiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Jasmin LienauDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Roberto LorbeerInstitute of Computer-Assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Bettina Lorenz-DepiereuxInstitute of Epidemiology, Helmholtz Center Munich, Munich, Germany.
Constanze Dorothea LüttkeBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Knut MaiDepartment of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Uta MerleDepartment of Internal Medicine IVM, University Hospital Heidelberg, Heidelberg, Germany.
Lil Antonia Meyer-ArndtBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Olga MiljukovInstitute of Clinical Epidemiology and Biometry, University Würzburg, Würzburg, Germany.
Maximilian MuenchhoffMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Ludwig-Maximilians-University Munich (LMU), Munich, Germany.
Moritz Müller-PlatheDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Julia NeuhannFaculty of Medicine, Institute of Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Hannelore NeuhauserDepartment of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
Alexandra NietersFaculty of Medicine, FREEZE-Biobank, Medical Center-University of Freiburg, Freiburg, Germany.
Christian OtteDepartment of Psychiatry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Daniel PapeDepartment of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
Rafaela Maria PintoBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christina PleyCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NUM Coordination Office, Berlin, Germany.
Annett PudszuhnDepartment of ENT, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Philipp ReukenDepartment of Internal Medicine IV, University Hospital Jena, Jena, Germany.
Siegberg RiegDivision of Infectious Diseases, Department of Medicine II, Faculty of Medicine, Medical Centre-University of Freiburg, Freiburg, Germany.
Petra RitterBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Gernot RohdeDepartment of Respiratory Medicine/Allergology, Medical Clinic 1, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.
Maria RönnefarthBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Michael RuzickaDepartment of Medicine III, University Hospital of Ludwig-Maximilians-University (LMU), Munich, Germany.
Jens SchallerInstitute of Computer-Assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Anne SchmidtBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Sein SchmidtBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Verena SchwachmeyerBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Georg SchwanitzBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Werner SeegerGerman Center for Lung Research (DZL), Institute of Lung Health (ILH), Excellence Cluster Cardiopulmonary Institute (CPI), Justus Liebig-University, Giessen, Germany.
Dana StahlIndependent Trusted Third Party, University Medicine Greifswald, Greifswald, Germany.
Nicole StobäusBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Hans Christian StubbeGerman Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Norbert SuttorpDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Bettina TemmesfeldDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Sylvia ThunBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Paul TrillerBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Frederik TrinkmannDepartment of Pneumology and Critical Care Medicine, Thoraxklinik, Translational Lung Research Center Heidelberg (TLRC), University of Heidelberg, Heidelberg, Germany.
Istvan VadaszGerman Center for Lung Research (DZL), Institute of Lung Health (ILH), Excellence Cluster Cardiopulmonary Institute (CPI), Justus Liebig-University, Giessen, Germany.
Heike ValentinIndependent Trusted Third Party, University Medicine Greifswald, Greifswald, Germany.
Maria VehreschildDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany.
Christof von KalleBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Marie von Lilienfeld-ToalDepartment of Internal Medicine II, Jena University Hospital, Jena, Germany.
Joachim WeberDepartment of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Tobias WelteBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christian WildbergDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Robert WizimirskiBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Saskia ZvorkBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Leif Erik SanderDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Janne VehreschildMedical Department 2, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
Thomas ZollerDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Florian KurthDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Martin WitzenrathDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany. martin.witzenrath@charite.de.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of acute and long-term morbidity and mortality worldwide despite global efforts in containment, prophylaxis, and therapy. With unprecedented speed, the global scientific community has generated pivotal insights into the pathogen and the host response evoked by the infection. However, deeper characterization of the pathophysiology and pathology remains a high priority to reduce morbidity and mortality of coronavirus disease 2019 (COVID-19).
methodsNAPKON-HAP is a multi-centered prospective observational study with a long-term follow-up phase of up to 36 months post-SARS-CoV-2 infection. It constitutes a central platform for harmonized data and biospecimen for interdisciplinary characterization of acute SARS-CoV-2 infection and long-term outcomes of diverging disease severities of hospitalized patients.
resultsPrimary outcome measures include clinical scores and quality of life assessment captured during hospitalization and at outpatient follow-up visits to assess acute and chronic morbidity. Secondary measures include results of biomolecular and immunological investigations and assessment of organ-specific involvement during and post-COVID-19 infection. NAPKON-HAP constitutes a national platform to provide accessibility and usability of the comprehensive data and biospecimen collection to global research.
conclusionNAPKON-HAP establishes a platform with standardized high-resolution data and biospecimen collection of hospitalized COVID-19 patients of different disease severities in Germany. With this study, we will add significant scientific insights and provide high-quality data to aid researchers to investigate COVID-19 pathophysiology, pathology, and chronic morbidity.
Indexed as
COVID-19GermanyHumansObservational Studies as TopicPandemicsQuality of LifeSARS-CoV-2CoronavirusCOVID-19Deep phenotypingInfectious diseaseSARS-CoV-2
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