Evidence map›Paper›PMID 37433874›Full record

ArticleNPJ digital medicine2023

Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices.

Akshay Khunte, Veer Sangha, Evangelos K Oikonomou, Lovedeep S Dhingra, Arya Aminorroaya, Bobak J Mortazavi, Andreas Coppi, Cynthia A Brandt, Harlan M Krumholz, Rohan Khera

Abstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

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  14. Robust AI-ECG for Predicting Left Ventricular Systolic Dysfunction in Pediatric Congenital Heart Disease.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akshay KhunteDepartment of Computer Science, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3812-3260
Veer SanghaDepartment of Computer Science, Yale University, New Haven, CT, USA.
Evangelos K OikonomouSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Lovedeep S DhingraSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5664-4126
Arya AminorroayaSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Bobak J MortazaviDepartment of Computer Science & Engineering, Texas A&M University, College Station, TX, USA.ORCID http://orcid.org/0000-0002-2655-2095
Andreas CoppiCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5243-552X
Cynthia A BrandtSection of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.
Harlan M KrumholzSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2046-127X
Rohan KheraSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. rohan.khera@yale.edu.ORCID http://orcid.org/0000-0001-9467-6199

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Evaluating and Improving Utilization of Evidence-Based Medical Therapy in Patients with Heart Failure using Automated Tools in the Electronic Health RecordK23HL153775 · NHLBI · YALE UNIVERSITY · PI KHERA, ROHAN · 2021 to 2025
$918k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL153775
6 · The paper itself

Abstract

Artificial intelligence (AI) can detect left ventricular systolic dysfunction (LVSD) from electrocardiograms (ECGs). Wearable devices could allow for broad AI-based screening but frequently obtain noisy ECGs. We report a novel strategy that automates the detection of hidden cardiovascular diseases, such as LVSD, adapted for noisy single-lead ECGs obtained on wearable and portable devices. We use 385,601 ECGs for development of a standard and noise-adapted model. For the noise-adapted model, ECGs are augmented during training with random gaussian noise within four distinct frequency ranges, each emulating real-world noise sources. Both models perform comparably on standard ECGs with an AUROC of 0.90. The noise-adapted model performs significantly better on the same test set augmented with four distinct real-world noise recordings at multiple signal-to-noise ratios (SNRs), including noise isolated from a portable device ECG. The standard and noise-adapted models have an AUROC of 0.72 and 0.87, respectively, when evaluated on ECGs augmented with portable ECG device noise at an SNR of 0.5. This approach represents a novel strategy for the development of wearable-adapted tools from clinical ECG repositories.

Identifiers

PMID37433874
PMCPMC10336107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.