Evidence map›Paper›PMID 37433843›Full record

ArticleScientific reports2023

Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study.

Jukka E Hintikka, Juha P Ahtiainen, Perttu Permi, Sirpa Jalkanen, Marko Lehtonen, Satu Pekkala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  15. Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jukka E HintikkaFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland. jukka.e.hintikka@jyu.fi.
Juha P AhtiainenFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Perttu PermiDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.
Sirpa JalkanenMediCity and InFLAMES Flagship, University of Turku, Turku, Finland.
Marko LehtonenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Satu PekkalaFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
University of Jyväskylä · FIUniversity of Eastern Finland · FIUniversity of Helsinki · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity is essential in weight management, improves overall health, and mitigates obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual exercise may improve gut's microbial diversity and increase the abundance of beneficial taxa in a correlated fashion. Since there is a lack of integrative omics studies on exercise and overweight populations, we studied the metabolomes and gut microbiota associated with programmed exercise in obese individuals. We measured the serum and fecal metabolites of 17 adult women with overweight during a 6-week endurance exercise program. Further, we integrated the exercise-responsive metabolites with variations in the gut microbiome and cardiorespiratory parameters. We found clear correlation with several serum and fecal metabolites, and metabolic pathways, during the exercise period in comparison to the control period, indicating increased lipid oxidation and oxidative stress. Especially, exercise caused co-occurring increase in levels of serum lyso-phosphatidylcholine moieties and fecal glycerophosphocholine. This signature was associated with several microbial metagenome pathways and the abundance of Akkermansia. The study demonstrates that, in the absence of body composition changes, aerobic exercise can induce metabolic shifts that provide substrates for beneficial gut microbiota in overweight individuals.

Indexed as

Gastrointestinal MicrobiomeOverweightAdultExerciseFemaleHumansLecithinsMultiomicsObesityLecithins

Identifiers

PMID37433843
PMCPMC10336137
OpenAlexW4383888030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.