Evidence map›Paper›PMID 37433779›Full record

ArticleTranslational psychiatry2023

BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study.

Jessica O'Loughlin, Francesco Casanova, Amanda Hughes, Zammy Fairhurst-Hunter, Liming Li, Zhengming Chen, China Kadoorie Biobank Collaborative Group, Jack Bowden, Ed Watkins, Rachel M Freathy and 3 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jessica O'LoughlinCollege of Biomedical and Clinical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-1519-3832
Francesco CasanovaCollege of Biomedical and Clinical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0003-0275-4765
Amanda HughesMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-5896-7650
Zammy Fairhurst-HunterClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Zhengming ChenClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
China Kadoorie Biobank Collaborative Group
Jack BowdenCollege of Biomedical and Clinical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Ed WatkinsDepartment of Psychology, University of Exeter, Exeter, UK.
Rachel M FreathyCollege of Biomedical and Clinical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Laura D HoweMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Robin G WaltersClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9179-0321
Jessica TyrrellCollege of Biomedical and Clinical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. j.tyrrell@exeter.ac.uk.ORCID 0000-0002-9256-6065
University of Exeter · GBUniversity of Bristol · GBUniversity of Oxford · GBPeking University · CN

Funding

British Heart Foundation CH/1996001/9454Cancer Research UK 29186Cancer Research UK C16077/A29186Cancer Research UK C500/A16896Department of HealthMedical Research Council MC-PC-13049Medical Research Council MC-PC-14135Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_00032/1Medical Research Council MC_UU_12026/2Medical Research Council MR/M020894/1Wellcome TrustWellcome Trust 088158/Z/09/ZWellcome Trust 104085/Z/14/ZWellcome Trust 202922/Z/16/ZWellcome Trust 212946/Z/18/ZWellcome Trust WT220390
6 · The paper itself

Abstract

Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations is limited. Here, we investigated the association between BMI and well-being in people of (a) East Asian and (b) European ancestry in the China Kadoorie Biobank (CKB) and UK Biobank (UKB), respectively. Mendelian randomisation (MR) methods were used to test the relationship between BMI with (a) health satisfaction and (b) life satisfaction. One-sample MR enabled us to test effects in men and women separately and to test the role of cultural contexts by stratifying our analyses by urban and rural home location in both China and the UK. Further, we implemented a control function method to test the linearity of the BMI-well-being relationship. We found evidence of different associations between BMI and well-being in individuals of East Asian versus European ancestry. For example, a genetically instrumented higher BMI tentatively associated with higher health satisfaction in people of East Asian ancestry, especially in females (ß: 0.041, 95% CI: 0.002, 0.081). In contrast, there was a robust inverse association between higher genetically instrumented BMI and health satisfaction in all European ancestry UKB participants (ß: -0.183, 95% CI: -0.200, -0.165, P

Indexed as

Body Mass IndexEast Asian PeopleEuropean PeopleHealth StatusAdultChinaFemaleHumansMale

Identifiers

PMID37433779
PMCPMC10336095
OpenAlexW4383878894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.