Evidence map›Paper›PMID 37433762›Full record

ArticleNature communications2023

Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.

Benoît Delignat-Lavaud, Jana Kano, Charles Ducrot, Ian Massé, Sriparna Mukherjee, Nicolas Giguère, Luc Moquin, Catherine Lévesque, Samuel Burke, Raphaëlle Denis and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  9. Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  10. Base editing ofeLife · 2024
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  18. Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Benoît Delignat-LavaudDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Jana Kano *Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Charles Ducrot *Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Ian MasséHôpital du Sacré-Cœur-de-Montréal, CIUSSS NIM, Université de Montréal, Montreal, QC, Canada.
Sriparna MukherjeeDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Nicolas GiguèreDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-8130-5321
Luc MoquinCentre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Catherine LévesqueFaculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.
Samuel BurkeDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Raphaëlle DenisDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0524-9385
Marie-Josée BourqueDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
Alex TchungDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-7000-7046
Pedro Rosa-NetoCentre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9116-1376
Daniel LévesqueFaculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3019-3048
Louis De BeaumontHôpital du Sacré-Cœur-de-Montréal, CIUSSS NIM, Université de Montréal, Montreal, QC, Canada.
Louis-Éric TrudeauDepartment of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. louis-eric.trudeau@umontreal.ca.ORCID http://orcid.org/0000-0003-4684-1377
Université de Montréal · CAResearch Network (United States) · USCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal · CAHôpital du Sacré-Cœur de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Parkinson's disease (PD), motor dysfunctions only become apparent after extensive loss of DA innervation. This resilience has been hypothesized to be due to the ability of many motor behaviors to be sustained through a diffuse basal tone of DA; but experimental evidence for this is limited. Here we show that conditional deletion of the calcium sensor synaptotagmin-1 (Syt1) in DA neurons (Syt1 cKO

Indexed as

DopamineParkinson DiseaseSynaptotagmin IAnimalsCalciumCorpus StriatumMiceNeostriatumNiacinamideCalciumDopamineNiacinamideSynaptotagmin ISyt1 protein, mouse

Identifiers

PMID37433762
PMCPMC10336101
OpenAlexW4383888069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.