ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Pattern separation of fear extinction memory.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Resetting the hippocampal buffer: a neurocognitive account of psychedelic therapy for anxiety-related psychopathology.Psychopharmacology · 2026Review
- Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis.Cognition · 2026Article
- Event Segmentation Promotes the Reorganization of Emotional Memory.Journal of cognitive neuroscience · 2025Article
- Emotional intensity produces a linear relationship on conditioned learning but an inverted U-shaped effect on episodic memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex.Current biology : CB · 2024Article
- Integrating and fragmenting memories under stress and alcohol.Neurobiology of stress · 2024Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
While fear generalizes widely, extinction is stimulus-specific. Using a hybrid conditioning/episodic memory paradigm, subjects encoded nonrepeating category exemplars during fear conditioning and extinction. Twenty-four hours later, a surprise memory test included old, similar, and novel category exemplars. Results showed strong dissociation between pattern completion (generalization) and pattern separation (discrimination) in episodic memory for items encoded during fear conditioning versus extinction, respectively. These data suggest that directly threat-conditioned stimuli are better recognized at the expense of mnemonic precision, whereas discrimination is enhanced for extinguished stimuli. Overly precise extinction memory may be a contributing factor to fear relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.