ArticleNature2023
De novo design of protein structure and function with RFdiffusion.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,024 papers.
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0cells of the map it votes in
1,024citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1,024 citing papers in PubMed.
- Artificial intelligence catalyzes antimicrobial peptide design.Synthetic and systems biotechnology · 2027Review
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- Prediction of antibody non-specificity using protein language models and biophysical parameters.mAbs · 2026Article
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- Mapping the TNFR2-targeting antibody patent landscape: Insights from macro trends to structural signatures.Human vaccines & immunotherapeutics · 2026Article
- Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins.Protein science : a publication of the Protein Society · 2026Article
- Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition.Molecular systems biology · 2026Article
- Graph-based representations in modern protein science.The Biochemical journal · 2026Review
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Multi-dimensional orchestration of binders for improved CAR-T immunotherapy.Cancer letters · 2026Review
- Beyond affinity: AI-supported developability assessment and multi-objective optimization in antibody development.Antibody therapeutics · 2026Review
- Hemoglobin-based oxygen carrier: what we have learned and where we are heading?Protein & cell · 2026Article
- Article
- Enhanced Sampling of Protein Conformations in AlphaFold3 with Repulsive Bias in the Diffusion Generative Model.JACS Au · 2026Article
- Degrading GPX4 via Biomimetic Nanoparticle-Mediated In Situ Synthesis of Deep-Learning-Designed Binder-Degron Chimeras for Prostate Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- AI-Designed TREM1-Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A designed ubiquitin-binding protein selectively enriches and visualizes unanchored ubiquitin.Science advances · 2026Article
- Antibody-drug conjugate engineering: from design to efficacy and safety.Signal transduction and targeted therapy · 2026Review
- Evolutionary Dynamics-AwareACS omega · 2026Article
- Quaternionic response geometry for proteins: toward a noncommutative theory of ordered deformations.Theory in biosciences = Theorie in den Biowissenschaften · 2026Article
964 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Joseph L Watson *Department of Biochemistry, University of Washington, Seattle, WA, USA.
David Juergens *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Nathaniel R Bennett *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8590-1454
Brian L Trippe *Institute for Protein Design, University of Washington, Seattle, WA, USA.
Jason Yim *Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0575-7400
Helen E Eisenach *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Woody Ahern *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Andrew J BorstDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4297-7824
Robert J RagotteDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Lukas F MillesDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8417-3205
Basile I M WickyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2501-7875
Nikita HanikelDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3292-5070
Samuel J PellockDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7557-7985
Alexis CourbetDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0539-7011
William ShefflerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jue WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Preetham VenkateshDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Isaac SappingtonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Susana Vázquez TorresDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Anna LaukoDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Valentin De BortoliNational Centre for Scientific Research, École Normale Supérieure rue d'Ulm, Paris, France.
Emile MathieuDepartment of Engineering, University of Cambridge, Cambridge, UK.
Sergey OvchinnikovFaculty of Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-2774-2744
Regina BarzilayMassachusetts Institute of Technology, Cambridge, MA, USA.
Tommi S JaakkolaMassachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-2199-0379
Frank DiMaioDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Minkyung BaekSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0003-3414-9404
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MProject 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI TIAN, LU · 2020 to 2024
$15.9MTRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6MNIA NIH HHS U19 AG065156NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM008268
Abstract
There has been considerable recent progress in designing new proteins using deep-learning methods
Indexed as
Deep LearningProteinsCatalytic DomainCryoelectron MicroscopyHemagglutinin Glycoproteins, Influenza VirusProtein BindingHemagglutinin Glycoproteins, Influenza VirusProteins
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.