Evidence map›Paper›PMID 37433044›Full record

ArticleACS chemical biology2023

Practical Synthesis of

Julia Thaler, Egor A Syroegin, Kathrin Breuker, Yury S Polikanov, Ronald Micura

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Julia ThalerInstitute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Egor A SyroeginDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0003-2753-3950
Kathrin BreukerInstitute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.ORCID 0000-0002-4978-0883
Yury S PolikanovDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-5064-0327
Ronald MicuraInstitute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.ORCID 0000-0003-2661-6105
Universität Innsbruck · ATUniversity of Illinois Chicago · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Advancing ribosome-targeting antibacterial peptides with a unique mechanism of actionR01AI162961 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALEXANDER S MANKIN, Terry William Moore · 2022 to 2026
$3.3M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Molecular mechanisms of action of ribosome-targeting antibiotics.R01GM132302 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2019 to 2022
$1.3M
Structural basis of Cfr-mediated resistance to antibiotics targeting the bacterial ribosomeR21AI163466 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2021 to 2022
$426k
Austrian Science Fund FWF P 31691NIAID NIH HHS R01 AI162961NIAID NIH HHS R21 AI163466NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM132302NIH HHS S10 OD021527
6 · The paper itself

Abstract

Hydrolysis-resistant RNA-peptide conjugates that mimic peptidyl-tRNAs are frequently needed for structural and functional studies of protein synthesis in the ribosome. Such conjugates are accessible by chemical solid-phase synthesis, allowing for the utmost flexibility of both the peptide and the RNA sequence. Commonly used protection group strategies, however, have severe limitations with respect to generating the characteristic

Indexed as

RNARNA, Transfer, Amino AcylPeptidesRibosomesPeptidesRNARNA, Transfer, Amino AcyltRNA, peptidyl-

Identifiers

PMID37433044
PMCPMC10594587
OpenAlexW4383896128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.