Evidence map›Paper›PMID 37432627›Full record

ArticleAdvances in experimental medicine and biology2023

The Epigenetic Landscape of Meningiomas.

Justin Z Wang, Farshad Nassiri, Kenneth Aldape, Andreas von Deimling, Felix Sahm

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. The Molecular and Immunological Landscape of Meningiomas.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin Z WangDivision of Neurosurgery, Department of Surgery, The University of Toronto, Toronto, ON, Canada.
Farshad NassiriDivision of Neurosurgery, Department of Surgery, The University of Toronto, Toronto, ON, Canada. farshad.nassiri@mail.utoronto.ca.
Kenneth AldapeLaboratory of Pathology, Center Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Andreas von DeimlingCCU Neuropathology, German Cancer Research Center (DKFZ), University Heidelberg, Heidelberg, Germany.
Felix SahmCCU Neuropathology, German Cancer Research Center (DKFZ), University Heidelberg, Heidelberg, Germany.

Funding

Development and validation of a predictor of meningioma recurrenceZIABC011847 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2018 to 2025
$5.9M
Genomic Biomarkers of CancerZIABC011850 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2019 to 2025
$5.1M
6 · The paper itself

Abstract

Epigenetic changes have been found to be increasingly important in tumor development and progression. These alterations can be present in tumors such as meningiomas in the absence of any gene mutations and alter gene expression without affecting the sequence of the DNA itself. Some examples of these alterations that have been studied in meningiomas include DNA methylation, microRNA interaction, histone packaging, and chromatin restructuring. In this chapter we will describe in detail each of these mechanisms of epigenetic modification in meningiomas and their prognostic significance.

Indexed as

Meningeal NeoplasmsMeningiomaChromatinDNA MethylationEpigenesis, GeneticHumansChromatinCDKN2ADNA methylationEpigeneticsH3K27me3HistoneMeningiomaMethylation groupPrognosticRecurrence

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.