Evidence map›Paper›PMID 37432562›Full record

ArticleJournal of racial and ethnic health disparities2024

Evaluating Disparities in Colon Cancer Survival in American Indian/Alaskan Native Patients Using the National Cancer Database.

Harika Nalluri, Schelomo Marmor, Saranya Prathibha, Asher Jenkins, Kassandra Dindinger-Hill, Michelle Kihara, Michael A Sundberg, Lukejohn W Day, Mary J Owen, Ann C Lowry and 1 more

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Article in Journal of racial and ethnic health disparities, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Harika NalluriDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Schelomo MarmorDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Saranya PrathibhaDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7144-8000
Asher JenkinsDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Kassandra Dindinger-HillDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Michelle KiharaDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Michael A SundbergDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Lukejohn W DayDivision of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, USA.
Mary J OwenDepartment of Family Medicine and BioBehavioral Health, University of Minnesota, Duluth, MN, USA.
Ann C LowryDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Todd M TuttleDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA. tuttl006@umn.edu.
University of Minnesota · USOffice of Minority Health · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies demonstrate higher mortality rates from colon cancer in American Indian/Alaskan Native (AI/AN) patients compared to non-Hispanic White (nHW). We aim to identify factors that contribute to survival disparities.

methodsWe used the National Cancer Database to identify AI/AN (n = 2127) and nHW (n = 527,045) patients with stage I-IV colon cancer from 2004 to 2016. Overall survival among stage I-IV colon cancer patients was estimated by Kaplan-Meier analysis; Cox proportional hazard ratios were used to identify independent predictors of survival.

resultsAI/AN patients with stage I-III disease had significantly shorter median survival than nHW (73 vs 77 months, respectively; p < 0.001); there were no differences in survival for stage IV. Adjusted analyses demonstrated that AI/AN race was an independent predictor of higher overall mortality compared to nHW (HR 1.19, 95% CI 1.01-1.33, p = 0.002). Importantly, compared to nHW, AI/AN were younger, had more comorbidities, had greater rurality, had more left-sided colon cancers, had higher stage but lower grade tumors, were less frequently treated at an academic facility, were more likely to experience a delay in initiation of chemotherapy, and were less likely to receive adjuvant chemotherapy for stage III disease. We found no differences in sex, receipt of surgery, or adequacy of lymph node dissection.

conclusionWe found patient, tumor, and treatment factors that potentially contribute to worse survival rates observed in AI/AN colon cancer patients. Limitations include the heterogeneity of AI/AN patients and the use of overall survival as an endpoint. Additional studies are needed to implement strategies to eliminate disparities.

Indexed as

American Indian or Alaska NativeColonic NeoplasmsAdultAgedAged, 80 and overDatabases, FactualFemaleHealth Status DisparitiesHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingUnited StatesWhiteAmerican Indian/Alaskan NativeColorectal cancerHealth equityRacial disparities

Identifiers

PMID37432562
OpenAlexW4383873035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.