Evidence map›Paper›PMID 37432561›Full record

ArticleJournal of racial and ethnic health disparities2024

Differences in Breast Cancers Among American Indian/Alaska Native and non-Hispanic Whites in the USA.

Anu G Gaba, Li Cao, Rebecca J Renfrew, DeAnn Witte, Janet M Wernisch, Abe E Sahmoun, Sanjay Goel, Kristi A Egland, Ross D Crosby

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In one paragraph

Article in Journal of racial and ethnic health disparities, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Anu G GabaSanford Roger Maris Cancer Center, Department of Medicine, University of North Dakota, 820 4th Street N, Fargo, ND, 58102, USA. Anu.gaba@sanfordhealth.org.ORCID 0000-0003-0619-5331
Li CaoSanford Center for Biobehavioral Research, Fargo, ND, USA.
Rebecca J RenfrewSanford Health, Fargo, ND, USA.
DeAnn WitteEli Lilly, Indianapolis, USA.ORCID 0000-0003-3246-4806
Janet M WernischSanford Health, Sioux Falls, SD, USA.ORCID 0000-0001-6937-1529
Abe E SahmounUniversity of North Dakota, Grand Forks, ND, USA.
Sanjay GoelRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.ORCID 0000-0002-2798-7568
Kristi A EglandSAB Biotherapeutics, Inc, Sioux Falls, SD, USA.ORCID 0000-0003-0141-6609
Ross D CrosbySanford Center for Biobehavioral Research, Fargo, ND, USA.ORCID 0000-0001-9131-1629
Sanford Health · USSanford Research · USEli Lilly (United States) · USRutgers, The State University of New Jersey · USSab Biotherapeutics (United States) · USUniversity of North Dakota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceBreast cancer (BC) death rates have not improved for American Indian/Alaska Native (AI/AN) women, whereas, it has significantly decreased for non-Hispanic White (White) women.

objectiveDelineate the differences in patient and tumor characteristics among AI/AN and Whites with BC, and its impact on age and stage at diagnosis as well as overall survival (OS).

methodsHospital-based, cohort study using the National Cancer Database to identify female AI/AN and Whites diagnosed with BC between the years 2004 and 2016.

resultsBC in 6866 AI/AN (0.3%) and 1,987,324 Whites (99.7%) were studied. The median age at diagnosis was 58 for AI/AN and 62 for Whites. AI BC patients traveled double the distance for treatment, lived in lower median income zip codes, had a higher percentage of uninsured, higher comorbidities, lower percentage of Stage 0/I, larger tumor size, greater number of positive lymph nodes, higher proportion of triple negative and HER2-positive BC than Whites. All the above comparisons were significant, p<0.001. Association between patient/tumor characteristics with age and stage at diagnosis was not significantly different between AI/AN and Whites. Unadjusted OS was worse for AI/AN as compared to Whites (HR=1.07, 95% CI=1.01-1.14, p=0.023). After adjustment of all covariates, OS was not different (HR=1.038, 95%CI=0.902-1.195, p=0.601).

conclusionThere were significant differences in patient/tumor characteristics among AI/AN and White BC which adversely impacted OS in AI/AN. However, when adjusted for various covariates, the survival was similar, suggesting that the worse survival in AI/AN is mostly the impact of known biological, socio-economic, and environmental determinants of health.

Indexed as

American Indian or Alaska NativeBreast NeoplasmsWhiteAdultAgedCohort StudiesFemaleHumansMiddle AgedNeoplasm StagingUnited StatesAmerican Indian/Alaska nativeBreast cancerNCDBSurvival

Identifiers

PMID37432561
OpenAlexW4383872159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.