Evidence map›Paper›PMID 37432549›Full record

ArticlePaediatric and perinatal epidemiology2024

Trajectories of cardiovascular risk predict pregnancy outcomes: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study.

Emily W Harville, Juuso O Hakala, Suvi P Rovio, Katja Pahkala, Olli Raitakari, Terho Lehtimäki

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Emily W HarvilleDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Juuso O HakalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Suvi P RovioResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
University of Turku · FITampere University of Applied Sciences · FITulane University · USTurku University Hospital · FI

Funding

EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
The Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9M
Long-Term Burden of Maternal Cardiovascular Risk Factors and Birth OutcomesR01HD069587 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI HARVILLE, EMILY WHEELER · 2012 to 2015
$2.1M
CHILDHOOD PREDICTOR OF ADULT CORONARY ARTERY DISEASER01HD032194 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI BERENSON, GERALD S · 1994 to 1998
–
European Research Council 742927NHLBI NIH HHSNHLBI NIH HHS P50 HL015103NIA NIH HHSNIA NIH HHS R01 AG016592NIA NIH HHS R01 AG041200NIA NIH HHS RF1 AG041200NICHD NIH HHS R01 HD032194NICHD NIH HHS R01 HD069587
6 · The paper itself

Abstract

backgroundLife course patterns of change in risk-trajectories-affect health.

objectivesTo examine how trajectories of cardiovascular risk factors are associated with pregnancy and birth outcomes.

methodsData from two cohort studies participating in the International Childhood Cardiovascular Consortium-The Bogalusa Heart Study (BHS; started in 1973, N = 903 for this analysis) and the Cardiovascular Risk in Young Finns Study (YFS; started in 1980, N = 499) were used. Both followed children into adulthood and measured cardiovascular risk factors, including body mass index (BMI), systolic and diastolic blood pressure (SBP/DBP), total, lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol and serum triglycerides. Discrete mixture modelling was used to divide each cohort into distinct trajectories according to these risk factors from childhood to early adulthood, and these groups were then used to predict pregnancy outcomes including small for gestational age (SGA; <10th study-specific percentile of gestational age by sex), preterm birth (PTB; <37 weeks' gestation), hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), with control for age at baseline and at first birth, parity, socioeconomic status, BMI and smoking.

resultsThe models created more trajectories for BMI, SBP and HDL-cholesterol in the YFS than in BHS, for which three classes generally seemed to be sufficient to represent the groups in the population across risk factors. In BHS, the association between the higher and flatter DBP trajectory and PTB was aRR 1.77, 95% confidence interval [CI] 1.06, 2.96. In BHS the association between consistent total cholesterol and PTB was aRR 2.16, 95% CI 1.22, 3.85 and in YFS the association between elevated high trajectory and PTB was aRR 3.35, 95% CI 1.28, 8.79. Elevated-increasing SBP was associated with a higher risk of GH in BHS and increasing or persistent-obese BMI trajectories were associated with GDM in both cohorts (BHS: aRR 3.51, 95% CI 1.95, 6.30; YFS: aRR 2.61, 95% CI 0.96, 7.08).

conclusionsTrajectories of cardiovascular risk, particularly those that represent a consistent or more rapid worsening of cardiovascular health, are associated with a higher risk of pregnancy complications.

Indexed as

Cardiovascular DiseasesDiabetes, GestationalPremature BirthChildCholesterolFemaleFinlandHeart Disease Risk FactorsHumansInfant, NewbornLongitudinal StudiesPregnancyRisk FactorsCholesterolbirthweightblood pressurelife courselipidspregnancy complicationstrajectory

Identifiers

PMID37432549
PMCPMC10782826
OpenAlexW4383872924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.