Evidence map›Paper›PMID 37432534›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Angiotensin II type 1 receptor antibodies and native kidney function in pediatric liver and intestinal transplant recipients.

Rachel Stern, Lucia Chen, Alvin P Chan, Laura J Wozniak, Meghan Pearl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rachel SternDepartment of Pediatric Nephrology, University of California Los Angeles, Los Angeles, CA, USA. rachelstern0@gmail.com.ORCID http://orcid.org/0000-0002-8028-9582
Lucia ChenDepartment of Medicine Statistics Core, University of California Los Angeles, Los Angeles, CA, USA.
Alvin P ChanDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, University of California Los Angeles, Los Angeles, CA, USA.
Laura J WozniakPediatric Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Meghan PearlDepartment of Pediatric Nephrology, University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

GASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0M
Understanding the Interface of Allo and Auto-Immunity: The Impact of Angiotensin II Type 1 Receptor Antibodies in Pediatric Kidney Transplant RecipientsK23AI139335 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PEARL, MEGHAN HALEY · 2019 to 2023
$1.0M
NIAID NIH HHS K23 AI139335NIDDK NIH HHS T32 DK007180
6 · The paper itself

Abstract

backgroundAngiotensin II type-1 receptor antibody (AT1R-Ab) has been associated with vascular injury and kidney dysfunction in pediatric kidney transplant recipients. The role of AT1R-Ab in the development of chronic kidney disease in pediatric liver and intestinal transplant recipients has not been explored.

methodsTwenty-five pediatric intestinal transplant recipients and 79 pediatric liver transplant recipients had AT1R-Ab levels measured at varying time points in the post-transplant period. Estimated glomerular filtration rate (eGFR) was determined using creatinine based CKiD U25 equation and measured at time of AT1R-Ab measurement, at 1 year post-AT1R-Ab measurement, at 5 years post-AT1R-Ab measurement, and at the most recent routine clinic visit. The prevalence of hypertension and antihypertensive medication use were also evaluated.

resultsYounger age at time of AT1R-Ab measurement was associated with AT1R-Ab positivity in liver transplant recipients. There was no association between AT1R-Ab status and change in eGFR, prevalence of hypertension, or use of antihypertensive medications at the described time points.

conclusionsAT1R-Ab positivity was not associated with a decline in eGFR or hypertension in pediatric liver and intestinal transplant recipients. Further studies are needed using other markers of kidney function, such as cystatin C, to validate this finding. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

HypertensionKidney TransplantationAntibodiesAntihypertensive AgentsChildGraft RejectionHumansKidneyLiverReceptor, Angiotensin, Type 1Transplant RecipientsAntibodiesAntihypertensive AgentsReceptor, Angiotensin, Type 1Angiotensin II type 1 receptor antibodyChronic kidney diseaseIntestine transplantLiver transplantNon-HLA antibody

Identifiers

PMID37432534
PMCPMC12767903
OpenAlexW4383873033

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.