Evidence map›Paper›PMID 37432351›Full record

ReviewNutrients2023

Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota.

William Fusco, Manuel Bernabeu Lorenzo, Marco Cintoni, Serena Porcari, Emanuele Rinninella, Francesco Kaitsas, Elena Lener, Maria Cristina Mele, Antonio Gasbarrini, Maria Carmen Collado and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 721 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
721citing papers in PubMed, 5 pooled it
150.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

721 citing papers in PubMed, 5 syntheses or guidelines pooled it, 978 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Trial
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  9. Article
  10. Gut microbes · 2026
    Article
  11. Article
  12. Gut microbes · 2026
    Article
  13. Review
  14. Article
  15. Gut microbial allies and adversaries in SARS-CoV-2 infection.Current research in microbial sciences · 2026
    Article
  16. Review
  17. Review
  18. Review
  19. c-Jun N-Terminal Kinase-2 Mediates Alcohol and Corticosterone-Induced Tissue Injury at the Gut-Liver Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  20. Article

661 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

William FuscoDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.
Manuel Bernabeu LorenzoInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), 46022 Valencia, Spain.ORCID 0000-0002-3011-5373
Marco CintoniDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-9610-0748
Serena PorcariDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.
Emanuele RinninellaDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-9165-2367
Francesco KaitsasDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.
Elena LenerDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.
Maria Cristina MeleDepartment of Translational Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-8463-7062
Antonio GasbarriniDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.ORCID 0000-0002-6230-1779
Maria Carmen ColladoInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), 46022 Valencia, Spain.ORCID 0000-0002-6204-4864
Giovanni CammarotaDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.
Gianluca IaniroDepartment of Medical and Surgical Sciences, Digestive Disease Center, Universitary Policlinic Agostino Gemelli Foundation IRCCS, 00168 Rome, Italy.ORCID 0000-0002-8318-0515
Università Cattolica del Sacro Cuore · ITInstituto de Agroquímica y Tecnología de Alimentos · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and cardiometabolic disorders. SCFAs are metabolites of specific bacterial taxa of the human gut microbiota, and their production is influenced by specific foods or food supplements, mainly prebiotics, by the direct fostering of these taxa. This Review provides an overview of SCFAs' roles and functions, and of SCFA-producing bacteria, from their microbiological characteristics and taxonomy to the biochemical process that lead to the release of SCFAs. Moreover, we will describe the potential therapeutic approaches to boost the levels of SCFAs in the human gut and treat different related diseases.

Indexed as

Gastrointestinal MicrobiomeBacteriaDietary SupplementsFatty Acids, VolatileHomeostasisHumansFatty Acids, Volatiledietgut healthgut microbiotaprebioticsprobioticsSCFA-producing bacteriashort-chain fatty acids

Identifiers

PMID37432351
PMCPMC10180739
OpenAlexW4381832905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.