Evidence map›Paper›PMID 37432316›Full record

ArticleeLife2023

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset.

Arian Mansur, Remi Joseph, Euri S Kim, Pierre M Jean-Beltran, Namrata D Udeshi, Cadence Pearce, Hanjie Jiang, Reina Iwase, Miroslav P Milev, Hashem A Almousa and 8 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Arian MansurDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Remi JosephDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Euri S KimDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Pierre M Jean-BeltranProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, United States.ORCID 0000-0001-5106-0992
Namrata D UdeshiProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, United States.
Cadence PearceProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, United States.
Hanjie JiangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Reina IwaseDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.ORCID 0000-0002-3703-2511
Miroslav P MilevDepartment of Biology, Concordia University of Edmonton, Montreal, Canada.
Hashem A AlmousaDepartment of Biology, Concordia University of Edmonton, Montreal, Canada.
Elyshia McNamaraFaculty of Health and Medical Sciences, Centre of Medical Research, Harry Perkins Institute of Medical Research, University of Western Australia, Perth, Australia.
Jeffrey WidrickDivision of Genetics, Boston Children's Hospital, Harvard Medical School, Boston, United States.
Claudio PerezDepartment of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Gianina RavenscroftFaculty of Health and Medical Sciences, Centre of Medical Research, Harry Perkins Institute of Medical Research, University of Western Australia, Perth, Australia.
Michael SacherDepartment of Biology, Concordia University of Edmonton, Montreal, Canada.
Philip A ColeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.ORCID 0000-0001-6873-7824
Steven A CarrProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, United States.
Vandana A GuptaDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.ORCID 0000-0002-4057-8451
Brigham and Women's Hospital · USBroad Institute · USConcordia University of Edmonton · CAThe University of Western Australia · AUBoston Children's Hospital · US

Funding

Chemical Approaches to Protein PhosphorylationR01CA074305 · NCI · JOHNS HOPKINS UNIVERSITY · PI COLE, PHILIP A · 2002 to 2025
$8.0M
Protein Acylation and Methylation Mechanisms_Administrative SupplementR37GM062437 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COLE, PHILIP A · 2013 to 2022
$4.1M
Kelch proteins in skeletal muscle development and diseasesR56AR077017 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI GUPTA, VANDANA · 2021 to 2021
$391k
Molecular Mechanisms of the Multi-Organ Response and Adaptation to ExerciseF32HL154711 · NHLBI · BROAD INSTITUTE, INC. · PI JEAN BELTRAN, PIERRE MICHEL · 2020 to 2021
$92k
NCI NIH HHS R01 CA074305NCI NIH HHS R01CA74305NHLBI NIH HHS F32 HL154711NHLBI NIH HHS F32HL154711NIAMS NIH HHS R56 AR077017NIAMS NIH HHS R56AR077017NIGMS NIH HHS R37 GM062437NIH HHS R37GM62437
6 · The paper itself

Abstract

Ubiquitin-proteasome system (UPS) dysfunction is associated with the pathology of a wide range of human diseases, including myopathies and muscular atrophy. However, the mechanistic understanding of specific components of the regulation of protein turnover during development and disease progression in skeletal muscle is unclear. Mutations in

Indexed as

Muscle ProteinsZebrafishAnimalsDisease ProgressionEndoplasmic ReticulumHumansMuscle DevelopmentMuscle, SkeletalProteomeSarcomeresUbiquitinUbiquitinationKLHL40 protein, humanMuscle ProteinsProteomeUbiquitincell biologydevelopmental biologygenetic diseasemyopathyskeletal muscleubiquitylationzebrafish

Identifiers

PMID37432316
PMCPMC10356137
OpenAlexW4383872229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.