Evidence map›Paper›PMID 37432300›Full record

SynthesisNutrients2023

The Effects of Creatine Supplementation Combined with Resistance Training on Regional Measures of Muscle Hypertrophy: A Systematic Review with Meta-Analysis.

Ryan Burke, Alec Piñero, Max Coleman, Adam Mohan, Max Sapuppo, Francesca Augustin, Alan A Aragon, Darren G Candow, Scott C Forbes, Paul Swinton and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 7 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 7 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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  10. Does creatine cause hair loss? A 12-week randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Ryan BurkeDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.ORCID 0000-0003-1201-2685
Alec PiñeroDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.ORCID 0000-0001-8186-1889
Max ColemanDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.
Adam MohanDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.ORCID 0009-0005-7860-1572
Max SapuppoDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.
Francesca AugustinDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.
Alan A AragonDepartment of Family and Consumer Sciences, California State University, Northridge, CA 91330, USA.
Darren G CandowFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada.
Scott C ForbesDepartment of Physical Education Studies, Faculty of Education, Brandon University, Brandon, MB R7A 6A9, Canada.ORCID 0000-0001-6896-5552
Paul SwintonSchool of Health Sciences, Robert Gordon University, Aberdeen AB10 7AQ, UK.ORCID 0000-0001-9663-0696
Brad J SchoenfeldDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY 10468, USA.
Lehman College · USBrandon University · CACalifornia State University, Northridge · USRobert Gordon University · GBUniversity of Regina · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this paper was to carry out a systematic review with a meta-analysis of randomized controlled trials that examined the combined effects of resistance training (RT) and creatine supplementation on regional changes in muscle mass, with direct imaging measures of hypertrophy. Moreover, we performed regression analyses to determine the potential influence of covariates. We included trials that had a duration of at least 6 weeks and examined the combined effects of creatine supplementation and RT on site-specific direct measures of hypertrophy (magnetic resonance imaging (MRI), computed tomography (CT), or ultrasound) in healthy adults. A total of 44 outcomes were analyzed across 10 studies that met the inclusion criteria. A univariate analysis of all the standardized outcomes showed a pooled mean estimate of 0.11 (95% Credible Interval (CrI): -0.02 to 0.25), providing evidence for a very small effect favoring creatine supplementation when combined with RT compared to RT and a placebo. Multivariate analyses found similar small benefits for the combination of creatine supplementation and RT on changes in the upper and lower body muscle thickness (0.10-0.16 cm). Analyses of the moderating effects indicated a small superior benefit for creatine supplementation in younger compared to older adults (0.17 (95%CrI: -0.09 to 0.45)). In conclusion, the results suggest that creatine supplementation combined with RT promotes a small increase in the direct measures of skeletal muscle hypertrophy in both the upper and lower body.

Indexed as

CreatineResistance TrainingAgedDietary SupplementsHumansHypertrophyMusclesCreatinelean massmuscle cross-sectional areamuscle thicknessnutritional supplementsstrength training

Identifiers

PMID37432300
PMCPMC10180745
OpenAlexW4367317704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.