Evidence map›Paper›PMID 37432152›Full record

Trial reportNutrients2023

Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food.

Svenja Meyhöfer, Rodrigo Chamorro, Manfred Hallschmid, Denisa Spyra, Nelli Klinsmann, Bernd Schultes, Hendrik Lehnert, Sebastian M Meyhöfer, Britta Wilms

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Sleep habits in the pathogenesis and management of diabesity.Journal of diabetes investigation · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Svenja MeyhöferInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.
Rodrigo ChamorroInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.
Manfred HallschmidGerman Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Denisa SpyraInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.
Nelli KlinsmannInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.
Bernd SchultesInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-5301-1163
Hendrik LehnertCenter of Brain, Behavior & Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Sebastian M MeyhöferInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.
Britta WilmsInstitute for Endocrinology and Diabetes, University of Lübeck, 23562 Lübeck, Germany.
Deutsches Diabetes-Zentrum e.V. · DEUniversity of Lübeck · DEUniversity of Salzburg · AT

Funding

Chilean National Commission for Scientific and Technological Research BECAS-CHILE 74170072Deutsche Forschungsgemeinschaft TR-SFB 654 ;TR-SFB 134German Center for Diabetes Research 01GI0925Vicerrectoría de Investigación y Desarrollo (VID)¸ Universidad de Chile 0278/2022
6 · The paper itself

Abstract

objectiveThere is evidence that reduced sleep duration increases hunger, appetite, and food intake, leading to metabolic diseases, such as type 2 diabetes and obesity. However, the impact of sleep timing, irrespective of its duration and on the regulation of hunger and appetite, is less clear. We aimed to evaluate the impact of sleep loss during the late vs. early part of the night on the regulation of hunger, appetite, and desire for food.

methodsFifteen normal-weight ([mean ± SEM] body-mass index: 23.3 ± 0.4 kg/m

resultsGhrelin and feelings of hunger and appetite, as well as the desire for food, were increased after 'late-night sleep loss', but not 'early-night sleep loss', whereas leptin remained unaffected by the timing of sleep loss.

conclusionsOur data indicate that timing of sleep restriction modulates the effects of acute sleep loss on ghrelin and appetite regulation in healthy men. 'Late-night sleep loss' might be a risk factor for metabolic diseases, such as obesity and type 2 diabetes. Thereby, our findings highlight the metabolic relevance of chronobiological sleep timing.

Indexed as

Appetite RegulationDiabetes Mellitus, Type 2GhrelinHumansLeptinMaleObesitySleepGhrelinLeptinappetite regulationghrelinhealthy menleptinsleep losssleep timing

Identifiers

PMID37432152
PMCPMC10181094
OpenAlexW4366827389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.