Evidence map›Paper›PMID 37432116›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2023

Hit 'em Where It Hurts: Gram-Negative Bacterial Lipopolysaccharide as a Vaccine Target.

Alan S Cross

Open access · hybridAbstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Assessment ofOpen veterinary journal · 2026
    Article
  2. Colistin Resistance in Bacteria: Current Updates on Mechanism of Action and Combating Strategies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  3. Deciphering defensive mechanisms inFrontiers in immunology · 2026
    Review
  4. Review
  5. NovelmBio · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Vaccines · 2024
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alan S CrossCenter for Vaccine Development and Global Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-4362-9936
University of Maryland, Baltimore · US

Funding

Probiotic yeast secreting single-domain antibodies to prevent Clostridium difficile and Campylobacter jejuni diseaseU19AI142725 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SZTEIN, MARCELO B. · 2019 to 2023
$12.5M
NIAID NIH HHS 5U19AI142725-03NIAID NIH HHS U19 AI142725
6 · The paper itself

Abstract

Infections with antimicrobial-resistant (AMR) bacteria pose an increasing threat to the ability to perform surgical procedures, organ transplantation, and treat cancer among many other medical conditions. There are few new antimicrobials in the development pipeline. Vaccines against AMR Gram-negative bacteria may reduce the use of antimicrobials and prevent bacterial transmission. This review traces the origins of lipopolysaccharide (LPS)-based vaccines against Gram-negative bacteria, the role of O polysaccharides and LPS core regions as potential vaccine targets, the development of new vaccine technologies, and their application to vaccines in current development.

Indexed as

Anti-Infective AgentsGram-Negative Bacterial InfectionsVaccinesAnti-Bacterial AgentsBacteriaGram-Negative BacteriaHumansLipopolysaccharidesAnti-Bacterial AgentsAnti-Infective AgentsLipopolysaccharidesVaccinesantimicrobial resistanceendotoxinGram-negative bacterialipopolysaccharideO polysaccharidevaccine

Identifiers

PMID37432116
PMCPMC10521362
OpenAlexW4383872238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.