Evidence map›Paper›PMID 37432034›Full record

ArticlemBio2023

Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.

Katharine M Ng, Sagar Pannu, Sijie Liu, Juan C Burckhardt, Thad Hughes, Will Van Treuren, Jen Nguyen, Kisa Naqvi, Bachviet Nguyen, Charlotte A Clayton and 3 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Gut Microbiota as a Mediator of Dietary Salt Effects on Blood Pressure.International journal of molecular sciences · 2026
    Review
  5. Article
  6. pH regulates gut bacterial tryptophan metabolism.NPJ biofilms and microbiomes · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Urease in acetogenicGut microbes · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Katharine M Ng *Department of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.ORCID 0000-0003-3494-5697
Sagar Pannu *Department of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.ORCID 0000-0002-9201-7621
Sijie LiuSchool of Biomedical Engineering, University of British Columbia , Vancouver, Canada.
Juan C BurckhardtDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.
Thad HughesIndependent Researcher , Vancouver, British Columbia, Canada.
Will Van TreurenDepartment of Microbiology and Immunology, Stanford University School of Medicine , Stanford, California, USA.
Jen NguyenDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.
Kisa NaqviSchool of Biomedical Engineering, University of British Columbia , Vancouver, Canada.
Bachviet NguyenDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.
Charlotte A ClaytonDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.
Deanna M PepinDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.
Samuel R CollinsDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.
Carolina TropiniDepartment of Microbiology and Immunology, University of British Columbia , Vancouver, Canada.ORCID 0000-0002-7542-1577
University of British Columbia · CACanadian Institute for Advanced Research · CAStanford University · US

Funding

CIHR
6 · The paper itself

Abstract

Changes to gut environmental factors such as pH and osmolality due to disease or drugs correlate with major shifts in microbiome composition; however, we currently cannot predict which species can tolerate such changes or how the community will be affected. Here, we assessed the growth of 92 representative human gut bacterial strains spanning 28 families across multiple pH values and osmolalities

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsBacteriaHumansHydrogen-Ion ConcentrationMiceOsmolar Concentrationacid stressculturomicsmachine learningmicrobiotaosmolalitysingle-strain culture

Identifiers

PMID37432034
PMCPMC10470613
OpenAlexW4383872867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.