Evidence map›Paper›PMID 37432019›Full record

ArticlemBio2023

Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung.

Daniel Murante, Elora G Demers, Tania Kurbessoian, Marina Ruzic, Alix Ashare, Jason E Stajich, Deborah A Hogan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Clinical and Molecular Advances on the Black YeastInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniel MuranteDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.ORCID 0000-0001-9909-4702
Elora G DemersDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.
Tania KurbessoianDepartment of Microbiology & Plant Pathology and Institute for Integrative Genome Biology, University of California-Riverside , Riverside, California, USA.
Marina RuzicDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.
Alix AshareDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.
Jason E StajichDepartment of Microbiology & Plant Pathology and Institute for Integrative Genome Biology, University of California-Riverside , Riverside, California, USA.ORCID 0000-0002-7591-0020
Deborah A HoganDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth , Hanover, New Hampshire, USA.ORCID 0000-0002-6366-2971
Dartmouth College · USUniversity of California, Riverside · US

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEAN R MADDEN · 2018 to 2026
$13.9M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Evolved Heterogeneity Contributes to Chronic Fungal Lung InfectionsR01AI127548 · NIAID · DARTMOUTH COLLEGE · PI HOGAN, DEBORAH A · 2017 to 2025
$3.9M
Regional Hypoxia Impacts the Heterogeneity of Inflammatory Lung DiseaseR01HL122372 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2015 to 2019
$2.0M
Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung InflammationK24HL150453 · NHLBI · DARTMOUTH-HITCHCOCK CLINIC · PI ASHARE, ALIX · 2020 to 2024
$542k
Molecular analysis of variable drug resistance in Candida lusitaniae isolatesF31AI133956 · NIAID · DARTMOUTH COLLEGE · PI DEMERS, ELORA G · 2018 to 2019
$90k
NHLBI NIH HHS K24 HL150453NHLBI NIH HHS R01 HL122372NIAID NIH HHS F31 AI133956NIAID NIH HHS R01 AI127548NIAID NIH HHS T32 AI007519NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

The genetic disease cystic fibrosis (CF) frequently leads to chronic lung infections by bacteria and fungi. We identified three individuals with CF with persistent lung infections dominated by

Indexed as

Cystic FibrosisExophialaFungiHumansIronLungPersistent InfectionIronCandida albicansClavispora lusitaniaecystic fibrosisExophiala dermatitidisfungiironMrs4

Identifiers

PMID37432019
PMCPMC10470810
OpenAlexW4383872364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.