Evidence map›Paper›PMID 37431832›Full record

ArticleJournal of dental research2023

The Oral Microbiome and Cross-Kingdom Interactions during Pregnancy.

C Gilbert Klaczko, N Alkhars, Y Zeng, M E Klaczko, A L Gill, D T Kopycka-Kedzierawski, T A Jusko, M B Sohn, J Xiao, S R Gill

Open access · hybridAbstract read
In one paragraph

Article in Journal of dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 9 citations in OpenAlex.

  1. Salivary OMICS factors associated with atopic dermatitis in early infancy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
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  4. Article
  5. Review
  6. Article
  7. Birth Cohort Study IdentifiesJournal of dental research · 2025
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

C Gilbert KlaczkoDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID 0000-0003-4865-5156
N AlkharsTranslational Biomedical Science Program, Clinical and Translational Science Institute, University of Rochester School of Medicine & Dentistry, USA.
Y ZengEastman Institute for Oral Health, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
M E KlaczkoChemistry Department, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-0478-0561
A L GillDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
D T Kopycka-KedzierawskiEastman Institute for Oral Health, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID 0000-0003-0798-6805
T A JuskoDepartment of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
M B SohnDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
J XiaoEastman Institute for Oral Health, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID 0000-0002-8776-2520
S R GillDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID 0000-0002-2408-1373
University of Rochester · USKuwait University · KW

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Steve N Georas · 1985 to 2026
$42.8M
Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancyR01DE031025 · NIDCR · UNIVERSITY OF ROCHESTER · PI STEVEN R. GILL, Tongtong Wu · 2022 to 2026
$3.9M
Association between Oral Candida albicans and the Onset of Severe Early Childhood CariesK23DE027412 · NIDCR · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2018 to 2022
$748k
Develop an Artificial Intelligence-powered Smartphone App AICaries for Caries Detection in ChildrenR21DE030251 · NIDCR · UNIVERSITY OF ROCHESTER · PI FISCELLA, KEVIN ANTHONY, LUO, JIEBO · 2021 to 2022
$421k
NIDCR NIH HHS K23 DE027412NIDCR NIH HHS R01 DE031025NIDCR NIH HHS R21 DE030251NIEHS NIH HHS P30 ES001247
6 · The paper itself

Abstract

Pregnancy initiates a temporary transition in the maternal physiological state, with a shift in the oral microbiome and a potential increase in frequency of oral diseases. The risk of oral disease is higher among populations of Hispanic and Black women and those with lower socioeconomic status (low SES), demonstrating a need for intervention within these high-risk populations. To further our understanding of the oral microbiome of high-risk pregnant women, we characterized the oral microbiome in 28 nonpregnant and 179 pregnant low-SES women during their third trimester living in Rochester, New York. Unstimulated saliva and supragingival plaque samples were collected cross-sectionally, followed by assessment of the bacterial (16S ribosomal RNA) and fungal (18S ITS) microbiota communities. Trained and calibrated dentists performed oral examinations to determine the number of decayed teeth and plaque index. Initially, plaque from 28 nonpregnant women and 48 pregnant women were compared; these data showed significant differences in bacterial abundances based on pregnancy status. To further our understanding of the oral microbiome within the pregnant population, we next examined the oral microbiome within this population based on several variables.

Indexed as

Dental CariesDental PlaqueMicrobiotaCandida albicansFemaleHumansLactobacillusPregnancySalivaStreptococcus mutansbiomarkerscariescaries detection/diagnosiscaries preventionrisk factor(s)social determinants

Identifiers

PMID37431832
PMCPMC10552463
OpenAlexW4383872733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.