Evidence map›Paper›PMID 37431768›Full record

ArticleEuropean stroke journal2023

Delivery of acute ischaemic stroke treatments in the European region in 2019 and 2020.

Diana Aguiar de Sousa, Arlene Wilkie, Bo Norrving, Chris Macey, Claudio Bassetti, Cristina Tiu, Greg Roth, Grethe Lunde, Hanne Christensen, Jens Fiehler and 9 more

Abstract read
In one paragraph

Article in European stroke journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
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  9. LiVE-STROKE: live video from bystander to the medical dispatcher in potential stroke cases.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
  10. Review
  11. Review
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  16. Trends in device utilization and procedural outcomes of endovascular treatment of acute ischemic stroke: A 10-year review of individual institutional experience.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  17. Revisiting Africa's Stroke Obstacles and Services (SOS).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  18. Delayed treatment of severe stroke: room for thrombectomy?European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  19. Drip and ship in patients with acute ischemic stroke: a narrative review.Therapeutic advances in neurological disorders · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Diana Aguiar de SousaStroke Center, Lisbon Central University Hospital and Faculty of Medicine, University of Lisbon, Lisbon, Portugal.ORCID 0000-0002-6702-7924
Arlene WilkieStroke Alliance for Europe, Brussels, Belgium.
Bo NorrvingDepartment of Clinical Sciences, Section of Neurology, Lund University, Skåne University Hospital, Lund, Sweden.
Chris MaceyIrish Heart Foundation, Dublin, Ireland.
Claudio BassettiDepartment of Neurology, Inselspital Bern and Medical Faculty, University of Bern, Bern, Switzerland.
Cristina TiuDepartment of Clinical Neurosciences, University of Medicine and Pharmacy 'Carol Davila' Bucharest, and Department of Neurology, University Hospital Bucharest, Romania.ORCID 0000-0001-8532-6218
Greg RothDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Grethe LundeStroke Alliance for Europe, Brussels, Belgium.
Hanne ChristensenDepartment of Neurology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.ORCID 0000-0002-7472-3194
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Francesca Romana PezzellaStroke Unit, Department of Neuroscience, San Camillo Forlanini Hospital, Rome, Italy.
Martin DichgansInstitute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University, Munich and German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Melinda B RoaldsenCenter for Research and Education, University Hospital of North Norway and Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-4848-9063
Peter KellyStroke and Neurology Department, Mater University Hospital and Stroke Clinical Trials Network Ireland, University College Dublin, Dublin, Ireland.ORCID 0000-0003-4772-6565
Robert MikulikInternational Clinical Research Center and Department of Neurology, St. Anne's University Hospital in Brno and Faculty of Medicine at Masaryk University, Brno, Czech Republic.ORCID 0000-0002-7458-5166
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences University of L'Aquila, L'Aquila, Italy.ORCID 0000-0003-0651-1939
Valeria CasoStroke Unit, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
Urs FischerDepartment of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.
Steering Committee for the Implementation of the Stroke Action Plan in Europe

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) and endovascular treatment (EVT) in the European region in 2019 and 2020. PATIENTS AND

methodsWe compared national data per number of inhabitants and per 100 annual incident first-ever ischaemic strokes (AIIS) in 46 countries. Population estimates and ischaemic stroke incidence were based on United Nations data and the Global Burden of Disease Report 2019, respectively.

resultsThe estimated mean number of acute SUs in 2019 was 3.68 (95% CI: 2.90-4.45) per one million inhabitants (MIH) with 7/44 countries having less than one SU per one MIH. The estimated mean annual number of IVTs was 21.03 (95% CI: 15.63-26.43) per 100,000 and 17.14% (95% CI: 12.98-21.30) of the AIIS in 2019, with highest country rates at 79.19 and 52.66%, respectively, and 15 countries delivering less than 10 IVT per 100,000. The estimated mean annual number of EVTs in 2019 was 7.87 (95% CI: 5.96-9.77) per 100,000 and 6.91% (95% CI: 5.15-8.67) of AIIS, with 11 countries delivering less than 1.5 EVT per 100,000. Rates of SUs, IVT and EVT were stable in 2020. There was an increase in mean rates of SUs, IVT and EVT compared to similar data from 2016.

conclusionAlthough there was an increase in reperfusion treatment rates in many countries between 2016 and 2019, this was halted in 2020. There are persistent major inequalities in acute stroke treatment in the European region. Tailored strategies directed to the most vulnerable regions should be prioritised.

Indexed as

Brain IschemiaEndovascular ProceduresIschemic StrokeStrokeHumansThrombolytic TherapyTreatment Outcomeacute stroke treatmentendovascular treatmentEuropehealth care resourcesintravenous thrombolysisstroke care implementationstroke unit

Identifiers

PMID37431768
PMCPMC10472963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.