ReviewThe veterinary quarterly2023
Mechanisms of circovirus immunosuppression and pathogenesis with a focus on porcine circovirus 2: a review.
Review in The veterinary quarterly, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Hijacking of host PCNA by circovirus replication-associated protein to recruit POLD1 drives viral DNA replication and is inhibited by R428.PLoS pathogens · 2026Article
- Development and Application of a Triplex qPCR Assay for the Simultaneous Detection of African Swine Fever Virus, Porcine Circovirus Type 2, and Porcine Circovirus Type 3.Veterinary sciences · 2026Article
- Detection of circovirus and herpesvirus co-infection in suddenly dead.Veterinary research communications · 2026Article
- Occurrence of diverse circoviruses in wild birds in Hungary.Veterinary research · 2026Article
- Emerging Challenges and Advances in Porcine Circovirus: A Decade in Review.Transboundary and emerging diseases · 2026Review
- Engineered PCV2 VLPs for Antigen Delivery: A Platform for Next-Generation Veterinary Vaccines.Transboundary and emerging diseases · 2026Review
- Circovirus infection in Croatian population of Eurasian griffon vultures (Gyps fulvus).Scientific reports · 2025Article
- Article
- Efficacy of a Novel PCV2d andVaccines · 2025Article
- Annexin A2 facilitates porcine circovirus type 2 infection by mediating viral attachment to host cells and interacting with the capsid protein.Veterinary research · 2025Article
- PCV2 Infection Represses the Differentiation of Light Zone Germinal Center B Cells by Inhibiting Their Interaction with Helper Cells.Microorganisms · 2025Article
- PCV2 Infection Upregulates SOCS3 Expression to Facilitate Viral Replication in PK-15 Cells.Viruses · 2025Article
- Comprehensive Survey of PCV2 and PCV3 in Domestic Pigs and Wild Boars Across Portugal: Prevalence, Geographical Distribution and Genetic Diversity.Pathogens (Basel, Switzerland) · 2025Article
- Metal-organic framework-based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2.Materials today. Bio · 2025Article
- Canine circovirus: emergence, adaptation, and challenges for animal and public health.Frontiers in veterinary science · 2025Review
- The single-cell transcriptional landscape of lung cells from PCV2d-infected mice.Frontiers in microbiology · 2025Article
- Occurrence of Recombinant Canine Coronavirus, Picodicistrovirus, and Circovirus in Red Foxes (Transboundary and emerging diseases · 2025Article
- Autophagy and porcine circovirus infection: a mini review.Frontiers in cellular and infection microbiology · 2025Review
- Assessment of a porcine circovirus type 2 vaccine prototype through anatomopathological analysis and its correlation with blood viral load.Frontiers in veterinary science · 2025Article
- A circovirus-like genomic sequence with unique architecture and phylogenetic relatedness to human-linked viral lineages.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Certain pathogens, due to their adverse effects on the immune reaction, aggravate the course of concomitant heterologous infections. Here we summarize mechanisms by which circoviruses, including the most studied porcine circovirus 2, and other mammalian and avian circoviruses, trigger their own replication and confound the hosts' immune response. At different stages of infection, from latent state to disease induction, these viruses markedly influence the cellular signaling pathways. Circoviruses have been found to interfere with interferon and proinflammatory cytokine producing and responsive pathways. Apoptotic processes, altered cellular transport and constraint of the mitotic phase all support the viral replication. The cytokine imbalance and lymphocyte depletion, thus the impaired immunity, favors invasion of super- or co-infecting agents, which in concert with circoviruses induce illnesses with increased severity. The information summarized in this review point out the diversity of host and viral factors involved in the mechanisms of disease progression during circovirus infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.