Evidence map›Paper›PMID 37431401›Full record

ArticleJCPP advances2021

Neurostructural correlates of retinal microvascular caliber in adolescent bipolar disorder.

Megan Mio, Kody G Kennedy, Mikaela Dimick, Alysha Sultan, Lisa Fiksenbaum, Beth Selkirk, Peter Kertes, Brian W McCrindle, Sandra E Black, Bradley J MacIntosh and 1 more

Abstract read
In one paragraph

Article in JCPP advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Article
  5. Beyond theJCPP advances · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Megan MioCentre for Youth Bipolar Disorder Centre for Addiction and Mental Health Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-7411-7995
Kody G KennedyCentre for Youth Bipolar Disorder Centre for Addiction and Mental Health Toronto Ontario Canada.
Mikaela DimickCentre for Youth Bipolar Disorder Centre for Addiction and Mental Health Toronto Ontario Canada.ORCID https://orcid.org/0000-0001-8371-1585
Alysha SultanCentre for Youth Bipolar Disorder Centre for Addiction and Mental Health Toronto Ontario Canada.
Lisa FiksenbaumSunnybrook Research Institute Sunnybrook Health Sciences Centre Toronto Ontario Canada.
Beth SelkirkDepartment of Ophthalmology and Vision Sciences John and Liz Tory Eye Centre Sunnybrook Health Sciences Centre Toronto Ontario Canada.
Peter KertesDepartment of Ophthalmology and Vision Sciences John and Liz Tory Eye Centre Sunnybrook Health Sciences Centre Toronto Ontario Canada.
Brian W McCrindleLabatt Family Heart Centre Hospital for Sick Children Toronto Ontario Canada.
Sandra E BlackHurvitz Brain Sciences Research Program Sunnybrook Health Sciences Centre Toronto Ontario Canada.
Bradley J MacIntoshHurvitz Brain Sciences Research Program Sunnybrook Health Sciences Centre Toronto Ontario Canada.
Benjamin I GoldsteinCentre for Youth Bipolar Disorder Centre for Addiction and Mental Health Toronto Ontario Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Vascular-brain associations are well established in adults but neglected in youth and psychiatric populations, who are at greater cardiovascular risk. We therefore examined the association of retinal vascular caliber with regional brain structure in adolescents with and without bipolar disorder (BD). Methods: One hundred and three adolescents ( Results: In the overall sample, arteriolar caliber was negatively associated with ACC volume ( Conclusion: This study provides evidence that vascular-brain associations are already evident in adolescence, suggesting that optimizing cardiovascular health may benefit the brain. This may be particularly relevant in BD and other brain disorders. Future research focusing on subpopulations where vascular-brain associations may be especially strong, for whom vascular-related interventions may be most indicated, is warranted.

Indexed as

adolescentbipolar disorderbrain structureretinal vessels

Identifiers

PMID37431401
PMCPMC10242848

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.