Evidence map›Paper›PMID 37431399›Full record

ArticleJCPP advances2021

Clinical validation of the parent-report Toronto Obsessive-Compulsive Scale (TOCS): A pediatric open-source rating scale.

Laura J Lambe, Christie L Burton, Evdokia Anagnostou, Elizabeth Kelley, Robert Nicolson, Stelios Georgiades, Noam Soreni, Russell J Schachar, Gregory L Hanna, Paul D Arnold and 1 more

Abstract read
In one paragraph

Article in JCPP advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura J LambeProgram of Neurosciences and Mental Health Hospital for Sick Children Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-7223-7854
Christie L BurtonProgram of Neurosciences and Mental Health Hospital for Sick Children Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-8955-6528
Evdokia AnagnostouBloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-3455-9887
Elizabeth KelleyDepartment of Psychology Queen's University Kingston Ontario Canada.
Robert NicolsonSchulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada.
Stelios GeorgiadesDepartment of Psychiatry & Behavioural Neurosciences McMaster University Hamilton Ontario Canada.
Noam SoreniDepartment of Psychiatry & Behavioural Neurosciences McMaster University Hamilton Ontario Canada.
Russell J SchacharProgram of Neurosciences and Mental Health Hospital for Sick Children Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-2015-4395
Gregory L HannaDepartment of Psychiatry University of Michigan Ann Arbor Michigan USA.
Paul D ArnoldThe Mathison Centre for Mental Health Research & Education Calgary Alberta Canada.ORCID https://orcid.org/0000-0003-2496-4624
Jennifer CrosbieProgram of Neurosciences and Mental Health Hospital for Sick Children Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-8710-3322

Funding

Action Monitoring and Genomic Variants in Pediatric Obsessive-Compulsive BehaviorR01MH101493 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARNOLD, PAUL DANIEL, GEHRING, WILLIAM J · 2013 to 2016
$2.3M
NIMH NIH HHS R01 MH101493
6 · The paper itself

Abstract

Background: There is a need to develop a multipurpose obsessive-compulsive disorder (OCD) measure that is useful for cross disorder research and as a reliable clinical rating scale. The current study examined the psychometric properties and established clinical cutoffs for the parent-report version of the Toronto Obsessive-Compulsive Scale (TOCS), a 21-item rating scale of obsessive-compulsive traits. Method: Participants ranged in age from 6 to 21 years old and had a primary diagnosis of OCD ( Results: The psychometric properties of the TOCS were confirmed. ROC analyses across TOCS scoring approaches in the discovery sample indicated excellent diagnostic discrimination (AUC ≥0.95, sensitivity 77%-92%, specificity 92%-98%). Established cutoffs, when applied in the independent validation sample of OCD cases and controls, showed an overall classification accuracy of 85%-90%. The TOCS total score and symptom count showed good discrimination of OCD from ADHD (AUC ≥0.86) and ASD (AUC ≥0.81). The OCD group scored significantly higher on all TOCS dimensions (except Hoarding) than the ADHD and ASD groups. Conclusion: The TOCS is a reliable and valid rating scale with strong sensitivity and specificity in discriminating OCD cases from controls, as well as from ASD and ADHD. It is a quantitative OCD measure with important clinical and research applications, with particular relevance for cross disorder phenotyping and population-based studies.

Indexed as

cross‐disorder phenotypingneurodevelopmental disordersobsessive–compulsive disorderobsessive–compulsive traitsROC analysisscale development

Identifiers

PMID37431399
PMCPMC10242913

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.