ArticleJCPP advances2023
Why we need families in genomic research on developmental psychopathology.
Article in JCPP advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood.Research square · 2026Article
- Indirect genetic effects of siblings.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Genetically Informed Research Designs in Perinatal Pharmacoepidemiology: A Methodological Overview.Drug safety · 2026Review
- Editorial: When children also shape the family environment.JCPP advances · 2026Article
- Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood.bioRxiv : the preprint server for biology · 2026Article
- Exploring educational field sorting using genetics.Nature genetics · 2025Article
- Genetic associations with educational fields.Nature genetics · 2025Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Raising the Floor? Genetic Influences on Educational Attainment Through the Lens of the Evolving Swedish Welfare State.Behavior genetics · 2025Article
- Social isolation and poor mental health in young people: testing genetic and environmental influences in a longitudinal cohort study.European child & adolescent psychiatry · 2025Article
- How early environment influences the developing brain and long-term mental health.JCPP advances · 2024Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.medRxiv : the preprint server for health sciences · 2023Article
- How to advance the understanding of multimorbidity in neurodevelopmental disorders using longitudinal research?JCPP advances · 2023Article
- Why we need families in genomic research on developmental psychopathology.JCPP advances · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Background: Fundamental questions about the roles of genes, environments, and their interplay in developmental psychopathology have traditionally been the domain of twin and family studies. More recently, the rapidly growing availability of large genomic datasets, composed of unrelated individuals, has generated novel insights. However, there are major stumbling blocks. Only a small fraction of the total genetic influence on childhood psychopathology estimated from family data is captured with measured DNA. Moreover, genetic influence identified using DNA is often confounded with indirect genetic effects of relatives, population stratification and assortative mating. Methods: The goal of this paper is to review how combining DNA-based genomic research with family-based quantitative genetics helps to address key issues in genomics and push knowledge further. Results: We focus on three approaches to obtaining more accurate and novel genomic findings on the developmental aetiology of psychopathology: (a) using knowledge from twin and family studies, (b) triangulating with twin and family studies, and (c) integrating data and methods with twin and family studies. Conclusion: We support the movement towards family-based genomic research, and show that developmental psychologists are particularly well-placed to contribute hypotheses, analysis tools, and data.
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