Evidence map›Paper›PMID 37431291›Full record

ArticleEpidemiology and psychiatric sciences2023

Substance use before or during pregnancy and the risk of child mortality, perinatal morbidities and congenital anomalies.

Charles Tzu-Chi Lee, Vincent Chin-Hung Chen, Johnny Kuang-Wu Lee, Shu-I Wu, Gillian Cheng, Tzu-Min Kao, Shih-Yuan Wang, Michael Gossop

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and psychiatric sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Charles Tzu-Chi LeeDepartment of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan.
Vincent Chin-Hung ChenDepartment of Psychiatry/Health Information and Epidemiology Laboratory, Chang Gung Memorial Hospital at Chiayi, Puzi, Taiwan.
Johnny Kuang-Wu LeeGeneral Education Center, University of Taipei, Taipei, Taiwan.
Shu-I WuDepartment of Medicine, Mackay Medical College, New Taipei, Taiwan.ORCID https://orcid.org/0000-0002-8461-5613
Gillian ChengDepartment of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan.
Tzu-Min KaoDepartment of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan.
Shih-Yuan WangDepartment of Exercise Health Science, National Taiwan University of Sports, Taichung City, Taiwan.
Michael GossopKing's College London, National Addiction Centre, London, UK.
National Taiwan Normal University · TWChang Gung University · TWKing's College London · GBMackay Memorial Hospital · TWNational Taiwan University of Sport · TWUniversity of Taipei · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe aimed to investigate child mortality, perinatal morbidities and congenital anomalies born by women with substance misuse during or before pregnancy (DP or BP).

methodsTaiwan Birth Registration from 2004 to 2014 linking Integrated Illicit Drug Databases used to include substance misuse participates. Children born by mothers convicted of substance misuse DP or BP were the substance-exposed cohort. Two substance-unexposed comparison cohorts were established: one comparison cohort selected newborns from the rest of the population on a ratio of 1:1 and exact matched by the child's gender, child's birth year, mother's birth year and child's first use of the health insurance card; another comparison cohort matched newborns from exposed and unexposed mothers by their propensity scores calculated from logistic regression.

resultsThe exposure group included 1776 DP, 1776 BP and 3552 unexposed individuals in exact-matched cohorts. A fourfold increased risk of deaths in children born by mothers exposed to substance during pregnancy was found compared to unexposed group (hazard ratio [HR] = 4.54, 95% confidence interval (CI): 2.07-9.97]. Further multivariate Cox regression models with adjustments and propensity matching substantially attenuated HRs on mortality in the substance-exposed cohort (aHR = 1.62, 95% CI: 1.10-2.39). Raised risks of perinatal morbidities and congenital anomalies were also found.

conclusionsIncreased risks of child mortality, perinatal morbidities or congenital anomalies were found in women with substance use during pregnancy. From estimates before and after adjustments, our results showed that having outpatient visits or medical utilizations during pregnancy were associated with substantially attenuated HRs on mortality in the substance-exposed cohort. Therefore, the excess mortality risk might be partially explained by the lack of relevant antenatal clinical care. Our finding may suggest that the importance of early identification, specific abstinence program and access to appropriate antenatal care might be helpful in reducing newborn mortality. Adequate prevention policies may be formulated.

Indexed as

Perinatal MortalitySubstance-Related DisordersChildFemaleHumansInfant, NewbornMorbidityMothersPolicyPregnancycongenital anomaliesmortalityperinatal morbiditiespregnancysubstance

Identifiers

PMID37431291
PMCPMC10387448
OpenAlexW4383872494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.