ArticlePediatric rheumatology online journal2023
Disability and disease-related damage in Thai children and adolescents with juvenile idiopathic arthritis.
Article in Pediatric rheumatology online journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- PAFLAR guidelines for oligoarticular juvenile idiopathic arthritis.Clinical rheumatology · 2026Guideline
- Symptoms and correlates of depression and anxiety in children and adolescents with juvenile idiopathic arthritis.Orphanet journal of rare diseases · 2026Article
- Multierosive Juvenile Idiopathic Arthritis With Positive Rheumatoid Factor: A Case Report of a Young Girl Followed at the University Clinics of Bukavu.Case reports in rheumatology · 2026Article
- Juvenile arthritis damage index predicts poor response to biological treatment: A prospective cohort study.World journal of clinical pediatrics · 2025Article
- Disease Damage in Juvenile Idiopathic Arthritis.Indian journal of pediatrics · 2025Article
- The Impact of 24-Month Etanercept Therapy on Changes in Adiponectin, Leptin and Tenascin C Levels in the Blood of Children with Juvenile Idiopathic Arthritis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Angular assessment of joints in juvenile idiopathic arthritis.Rheumatology and immunology research · 2025Article
- Risk factors for growth retardation in children with juvenile idiopathic arthritis: a case-control study.BMC musculoskeletal disorders · 2025Article
- Global burden and genetic insights of RA and JIA in ages 0-19 years: GBD 2021 and MR analysis.Frontiers in immunology · 2025Article
- Inflammation-induced leg length discrepancy in children: from molecular mechanisms to clinical implications.Frontiers in medicine · 2025Review
- Prevalence of HLA-B27, clinical characteristics and treatment outcomes in children with enthesitis-related arthritis.BMC pediatrics · 2024Article
- Implementation and assessment of a structured curriculum for a 4-week pediatric rheumatology rotation for pediatric residents.BMC medical education · 2024Article
- Panniculitis with late onset enthesitis-related arthritis: a case report.Pediatric rheumatology online journal · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren and adolescents with juvenile idiopathic arthritis (JIA) may suffer from disability and disease-related damage. This study aimed to investigate the prevalence of disability and damage, and identify the factors associated with articular and extra-articular damage in children and adolescents with JIA in a resource-restricted setting in Thailand.
methodsThis cross-sectional study enrolled JIA patients during June 2019-June 2021. Disability was assessed using the Child Health Assessment Questionnaire (CHAQ) and Steinbrocker classification criteria. Damage was evaluated using the Juvenile Arthritis Damage Index (JADI) and the modified-JADI (mJADI) tools.
resultsThere were 101 patients (50.5% female) with median age of 11.8 years. Median disease duration was 32.7 months. Enthesitis-related arthritis (ERA) was the most common subtype (33.7%), followed by systemic JIA (25.7%). Thirty-three (32.7%) patients had delayed diagnosis ≥ 6 months. Moderate to severe disability was found in 20 (19.8%) patients. Patients with Steinbrocker functional classification > class I were seen in 17.9%. Thirty-seven (36.6%) patients had articular damage. Extra-articular complications were observed in 24.8%. Growth failure and striae were the most common complications in 7.8%. Leg-length discrepancy was documented in 5.0%. Ocular damage was found in 1 patient with ERA. Multivariable logistic regression analysis revealed Steinbrocker functional classification > class I (aOR: 18.1, 95% CI: 3.9-84.6; p < 0.001), delayed diagnosis ≥ 6 months (aOR: 8.5, 95%CI: 2.7-27.0; p < 0.001), and ERA (aOR: 5.7, 95%CI: 1.8-18.3; p = 0.004) as independent predictors of articular damage. Systemic corticosteroids use was the independent predictor of extra-articular damage (aOR: 3.8, 95%CI: 1.3-11.1; p = 0.013).
conclusionsDisability and disease-related damage was identified in one-fifth and one-third of JIA patients. Early detection and treatment are essential for preventing permanent damage.
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