Evidence map›Paper›PMID 37430239›Full record

ArticleBMC infectious diseases2023

Clinical significance of B7-H3 expression in circulating CD4

Jun-Chi Xu, Hui Chen, Ping Xu, Xin-Ran You, Geng-Chao Zhu, Fei Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jun-Chi Xu *The Fifth People's Hospital of Suzhou, China. 10, Guangqian Road, Suzhou, Jiangsu, 215000, P. R. China. xujunchi19850504@126.com.
Hui Chen *The Fifth People's Hospital of Suzhou, China. 10, Guangqian Road, Suzhou, Jiangsu, 215000, P. R. China.
Ping Xu *The Fifth People's Hospital of Suzhou, China. 10, Guangqian Road, Suzhou, Jiangsu, 215000, P. R. China.
Xin-Ran YouThe Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, Jiangsu, P. R. China.
Geng-Chao ZhuThe Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, Jiangsu, P. R. China.
Fei GaoThe Affiliated Suzhou Hospital of Nanjing Medical University, 26 Daoqian Road, Suzhou, Jiangsu, P. R. China. coffee_201314@126.com.
Suzhou Municipal Hospital · CNThe Fifth People’s Hospital of Suzhou · CN

Funding

National Natural Science Foundation of China 81900577Natural Fund of Jiangsu Province, China BZ2019017Suzhou Gusu Health Talents Program of Suzhou GSWS2019067the Science and Technology Plan of Suzhou, China SYS2020192Young Medical Talents Program of Jiangsu QNRC2016225
6 · The paper itself

Abstract

backgroundB7-H3 is an important immune checkpoint molecule that plays a negative role in immune regulation. This study was aimed to explore B7-H3 expression in HIV-infected patients and its clinical significance.

methodsTo explore the expression and clinical significance of B7-H3 in HIV-infected patients, we investigated the B7-H3 expression pattern and the correlation of B7-H3 expression with clinical parameters of HIV-infected patients with different levels of CD4

resultsB7-H3 expression in HIV-infected patients was significantly higher than that in healthy controls. mB7-H3 expression on CD4

conclusionsB7-H3 played an important negative regulatory role in anti-HIV infection immunity. It could be used as a potential biomarker for the progression of HIV infection and a novel target for the treatment of HIV infection.

Indexed as

CD8-Positive T-LymphocytesHIV InfectionsBiological AssayClinical RelevanceHumansMonocytesPlasmaTranscription FactorsTranscription FactorsB7-H3CD4+CD25high T cellsHIV infectionMonocytesProgression

Identifiers

PMID37430239
PMCPMC10334634
OpenAlexW4383742770

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.