Evidence map›Paper›PMID 37430186›Full record

ArticleBMC genomics2023

Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population.

Janet X Li, Kleinberg X Fernandez, Carol Ritland, Sharon Jancsik, Daniel B Engelhardt, Lauren Coombe, René L Warren, Marco J van Belkum, Allan L Carroll, John C Vederas and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Janet X LiMichael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada. janli@bcgsc.ca.
Kleinberg X FernandezDepartment of Chemistry, University of Alberta, 11227 Saskatchewan Drive NW, Edmonton, AB, T6G 2G2, Canada.
Carol RitlandMichael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Sharon JancsikMichael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Daniel B EngelhardtDepartment of Chemistry, University of Alberta, 11227 Saskatchewan Drive NW, Edmonton, AB, T6G 2G2, Canada.
Lauren CoombeCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 W 7th Ave #100, Vancouver, BC, V5Z 4S6, Canada.
René L WarrenCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 W 7th Ave #100, Vancouver, BC, V5Z 4S6, Canada.
Marco J van BelkumDepartment of Chemistry, University of Alberta, 11227 Saskatchewan Drive NW, Edmonton, AB, T6G 2G2, Canada.
Allan L CarrollDepartment of Forest and Conservation Sciences, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
John C VederasDepartment of Chemistry, University of Alberta, 11227 Saskatchewan Drive NW, Edmonton, AB, T6G 2G2, Canada.
Joerg BohlmannMichael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC, V6T 1Z4, Canada.
Inanc BirolCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, 570 W 7th Ave #100, Vancouver, BC, V5Z 4S6, Canada.
Canada's Michael Smith Genome Sciences Centre · CAUniversity of Alberta · CABC Cancer Agency · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mountain pine beetle, Dendroctonus ponderosae, is an irruptive bark beetle that causes extensive mortality to many pine species within the forests of western North America. Driven by climate change and wildfire suppression, a recent mountain pine beetle (MPB) outbreak has spread across more than 18 million hectares, including areas to the east of the Rocky Mountains that comprise populations and species of pines not previously affected. Despite its impacts, there are few tactics available to control MPB populations. Beauveria bassiana is an entomopathogenic fungus used as a biological agent in agriculture and forestry and has potential as a management tactic for the mountain pine beetle population. This work investigates the phenotypic and genomic variation between B. bassiana strains to identify optimal strains against a specific insect.

resultsUsing comparative genome and transcriptome analyses of eight B. bassiana isolates, we have identified the genetic basis of virulence, which includes oosporein production. Genes unique to the more virulent strains included functions in biosynthesis of mycotoxins, membrane transporters, and transcription factors. Significant differential expression of genes related to virulence, transmembrane transport, and stress response was identified between the different strains, as well as up to nine-fold upregulation of genes involved in the biosynthesis of oosporein. Differential correlation analysis revealed transcription factors that may be involved in regulating oosporein production.

conclusionThis study provides a foundation for the selection and/or engineering of the most effective strain of B. bassiana for the biological control of mountain pine beetle and other insect pests populations.

Indexed as

BeauveriaColeopteraAnimalsBenzoquinonesGenomicsVirulenceBenzoquinonesoosporeinBeauveria bassianaForest health genomicsFungal metabolismPest control

Identifiers

PMID37430186
PMCPMC10334655
OpenAlexW4383702550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.