Evidence map›Paper›PMID 37430176›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Prognosis and follow-up of patients with prosthetic valve endocarditis treated conservatively in relation to WBC-SPECT imaging.

Julia Grambow-Velilla, Besma Mahida, Khadija Benali, Laurene Deconinck, Caroline Chong-Nguyen, Claire Cimadevilla, Xavier Duval, Bernard Iung, François Rouzet, Fabien Hyafil

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Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Julia Grambow-VelillaDepartment of Nuclear Medicine, AP-HP, European Hospital Georges-Pompidou, University of Paris-Cité, 75015, Paris, France.
Besma MahidaDepartment of Nuclear Medicine, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Khadija BenaliDepartment of Nuclear Medicine, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Laurene DeconinckDepartment of Infectious Diseases, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Caroline Chong-NguyenDepartment of Cardiology, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Claire CimadevillaDepartment of Cardiology, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Xavier DuvalDepartment of Infectious Diseases, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Bernard IungDepartment of Cardiology, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
François RouzetDepartment of Nuclear Medicine, AP-HP, Bichat University Hospital, University of Paris-Cité, 75018, Paris, France.
Fabien HyafilDepartment of Nuclear Medicine, AP-HP, European Hospital Georges-Pompidou, University of Paris-Cité, 75015, Paris, France. fabien.hyafil@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur objective was to evaluate in patients with prosthetic valve endocarditis (PVE) treated conservatively, the prognostic value of white blood cell (WBC) signal intensity on SPECT and to describe the evolution of the WBC signal under antibiotics.

methodsPatients with PVE treated conservatively and positive WBC-SPECT imaging were identified retrospectively. Signal intensity was classified as intense if equal to or higher, or mild if lower, than the liver signal. Clinical, biological, imaging and follow-up information were collected from medical files.

resultsAmong 47 patients, WBC signal was classified as intense in 10 patients and as mild, in 37. The incidence of the primary composite endpoint (death, late cardiac surgery, or relapse) was significantly higher in patients with intense vs. mild signal (90% vs. 11%). Twenty-five patients underwent a second WBC-SPECT imaging during follow-up. The prevalence of WBC signal decreased progressively from 89% between 3 and 6 weeks to 42% between 6 and 9 weeks and 8% more than 9 weeks after initiation of antibiotics.

conclusionsIn patients with PVE treated conservatively, intense WBC signal was associated with poor outcome. WBC-SPECT imaging appears as an interesting tool for risk stratification and to monitor locally the efficacy of antibiotic treatment.

Indexed as

EndocarditisEndocarditis, BacterialHeart Valve ProsthesisProsthesis-Related InfectionsAnti-Bacterial AgentsFollow-Up StudiesHumansLeukocytesPrognosisRetrospective StudiesTomography, Emission-Computed, Single-PhotonAnti-Bacterial Agentsfollow-upProsthetic valve endocarditisscintigraphyWBC-SPECT imaging

Identifiers

PMID37430176

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