Evidence map›Paper›PMID 37429941›Full record

ArticleNature materials2023

Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics.

Claudia Cea, Zifang Zhao, Duncan J Wisniewski, George D Spyropoulos, Anastasios Polyravas, Jennifer N Gelinas, Dion Khodagholy

Abstract read
In one paragraph

Article in Nature materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Neuromorphic Devices and Computing for Sensing, Memory, and Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Implantable bioelectronic outlet.Science advances · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Broadly applicable hydrophilic additive enhances electrochemical transistor function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Review
  12. Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Article
  14. Dynamic Modulation of OECT-Based Inverters for In Situ Electrophysiological Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claudia Cea *Department of Electrical Engineering, Columbia University, New York, NY, USA.
Zifang Zhao *Department of Electrical Engineering, Columbia University, New York, NY, USA.
Duncan J WisniewskiDepartment of Electrical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-5405-1258
George D SpyropoulosDepartment of Electrical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-6648-5758
Anastasios PolyravasDepartment of Electrical Engineering, Columbia University, New York, NY, USA.
Jennifer N GelinasDepartment of Neurology, Columbia University Medical Center, New York, NY, USA. jng2146@cumc.columbia.edu.ORCID 0000-0002-1164-638X
Dion KhodagholyDepartment of Electrical Engineering, Columbia University, New York, NY, USA. dk2955@columbia.edu.ORCID 0000-0003-0805-4612

Funding

Closed-Loop Modulation of Hippocampal-Cortical Communication in Temporal Lobe EpilepsyR01NS118091 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Jennifer Gelinas · 2021 to 2026
$2.0M
Organic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)RF1NS128669 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KHODAGHOLY, DION · 2022 to 2022
$1.5M
Conformable, Expandable Neural Interface Device for the developing brainR21EY032381 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GELINAS, JENNIFER, KHODAGHOLY, DION · 2021 to 2022
$463k
NEI NIH HHS R21 EY032381NINDS NIH HHS R01 NS118091NINDS NIH HHS RF1 NS128669
6 · The paper itself

Abstract

Organic electronics can be biocompatible and conformable, enhancing the ability to interface with tissue. However, the limitations of speed and integration have, thus far, necessitated reliance on silicon-based technologies for advanced processing, data transmission and device powering. Here we create a stand-alone, conformable, fully organic bioelectronic device capable of realizing these functions. This device, vertical internal ion-gated organic electrochemical transistor (vIGT), is based on a transistor architecture that incorporates a vertical channel and a miniaturized hydration access conduit to enable megahertz-signal-range operation within densely packed integrated arrays in the absence of crosstalk. These transistors demonstrated long-term stability in physiologic media, and were used to generate high-performance integrated circuits. We leveraged the high-speed and low-voltage operation of vertical internal ion-gated organic electrochemical transistors to develop alternating-current-powered conformable circuitry to acquire and wirelessly communicate signals. The resultant stand-alone device was implanted in freely moving rodents to acquire, process and transmit neurophysiologic brain signals. Such fully organic devices have the potential to expand the utility and accessibility of bioelectronics to a wide range of clinical and societal applications.

Indexed as

Transistors, ElectronicAnimalsMiceRats

Identifiers

PMID37429941
PMCPMC10533388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.