ArticleNature neuroscience2023
How coupled slow oscillations, spindles and ripples coordinate neuronal processing and communication during human sleep.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.Molecular psychiatry · 2025Trial
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- Sleep spindle deficits in childhood absence epilepsy improve with antiseizure treatment and disease resolution.bioRxiv : the preprint server for biology · 2026Article
- Article
- Human brain-wide activation of sleep rhythms.eLife · 2026Article
- Propofol-Facilitated Recovery Sleep Modulates Cognitive Function via Slow Oscillation-Spindle Coupling After Acute Sleep Deprivation in Rats.CNS neuroscience & therapeutics · 2026Article
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- Observational
- Hearing in Our Sleep-Can We Drown Out Epileptic Spikes and Boost Cognition?Epilepsy currents · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Differential Nap-To-Nap Stability of Sleep Spindles, Slow Waves, and their Temporal Coupling: An Exploratory Study.Journal of sleep research · 2026Article
- The Effect of Closed-Loop Auditory Stimulation on Memory Consolidation and Sleep Physiology in an Ecological Setting.Journal of sleep research · 2026Article
- Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults.bioRxiv : the preprint server for biology · 2026Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Communications biology · 2026Article
- Sleep strengthens successor representations of learned sequences in humans.PLoS biology · 2026Article
- Aperiodic and periodic neural activity during sleep in autism spectrum disorders.BMC medicine · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep.Nature neuroscience · 2026Article
- Article
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning and plasticity rely on fine-tuned regulation of neuronal circuits during offline periods. An unresolved puzzle is how the sleeping brain, in the absence of external stimulation or conscious effort, coordinates neuronal firing rates (FRs) and communication within and across circuits to support synaptic and systems consolidation. Using intracranial electroencephalography combined with multiunit activity recordings from the human hippocampus and surrounding medial temporal lobe (MTL) areas, we show that, governed by slow oscillation (SO) up-states, sleep spindles set a timeframe for ripples to occur. This sequential coupling leads to a stepwise increase in (1) neuronal FRs, (2) short-latency cross-correlations among local neuronal assemblies and (3) cross-regional MTL interactions. Triggered by SOs and spindles, ripples thus establish optimal conditions for spike-timing-dependent plasticity and systems consolidation. These results unveil how the sequential coupling of specific sleep rhythms orchestrates neuronal processing and communication during human sleep.
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