ArticleNature neuroscience2023
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca
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Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
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Who cites it
47 citing papers in PubMed, 61 citations in OpenAlex.
- A single-center clinical trial evaluating topical propranolol for preventing stress-induced hair loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Trial
- Amyloid-Forming Amylin Secreted by the Pancreas Promotes Hypoxia-Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis.Comprehensive physiology · 2026Article
- Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice.Nature communications · 2026Article
- Clustering Properties of Neuronal Ryanodine Receptor 2 and Remodeling in the APP/PS1 Mouse Model of Alzheimer's Disease.Acta physiologica (Oxford, England) · 2026Article
- Cardiac Rehabilitation and Cognitive Impairment: Elective Affinities or Fatal Attraction.Journal of clinical medicine · 2026Review
- Calbindin-D28k deficiency mediates tau-driven hippocampal hyperexcitement and cognitive impairment.Translational neurodegeneration · 2026Article
- SLC22A3 deficiency leads to cognitive impairment through the cardio-neuroinflammatory axis mediated HA/H1R/NLRP3 pathway in heart failure mice.Redox biology · 2026Article
- Incidence and impact of brain lesions and cognitive impairment after CABG with moderate or severe cerebral artery stenosis seen on low-field MRI.Stroke and vascular neurology · 2026Article
- Metabolism-Mediated Regulation of Brain-Heart Interactions.International journal of molecular sciences · 2026Review
- Canonical Wnt signaling affects calcium homeostasis in serum-treated AC16 cells through MLN-mediated SERCA2a regulation.Journal of molecular cell biology · 2026Article
- Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia-reperfusion.BMC medicine · 2026Article
- Homovanillic acid improves anxiety by regulating F4/80+ microglia/macrophage in adult mice with neonatal cardiac injury.Scientific reports · 2026Article
- Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis.Biomedicines · 2026Review
- The Heart-Brain Axis in the Context of Cardiovascular Disease.Physiology (Bethesda, Md.) · 2026Review
- The emerging role of calsequestrin 2: from calcium sensor and modulator to arrhythmia driver.Journal of physiology and biochemistry · 2026Review
- Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases.Signal transduction and targeted therapy · 2026Review
- Endothelial epigenetic senescence driven microglial activation mediates cardio-retinal neuroinflammation in heart failure.Theranostics · 2026Article
- Ventricular cardiac magnetic resonance traits and schizophrenia risk: a UK Biobank and Mendelian randomization study.Frontiers in psychiatry · 2026Article
- Microglia-Neuron Interactions in Alzheimer's Disease.Current neuropharmacology · 2026Review
- Autophagy-Lysosome Pathway Dysfunction in Neurodegeneration and Cancer: Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Haikel DridiDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA. dh2756@cumc.columbia.edu.ORCID 0000-0001-9533-7367
Yang LiuDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.ORCID 0000-0002-8343-4431
Steven ReikenDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.ORCID 0000-0002-5807-3574
Xiaoping LiuDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Elentina K ArgyrousiTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.ORCID 0000-0003-3716-807X
Qi YuanDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.
Marco C MiottoDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA.ORCID 0000-0001-8851-4863
Leah SittenfeldORCID 0000-0001-8349-0663
Andrei MeddarORCID 0000-0002-2708-6153
Rajesh Kumar SoniProteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, New York, NY, USA.
Ottavio ArancioTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.ORCID 0000-0001-6335-164X
Alain LacampagnePHYMEDEXP, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.
Andrew R MarksDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY, USA. arm42@cumc.columbia.edu.ORCID 0000-0002-4316-5775
Columbia University · USCentre National de la Recherche Scientifique · FRHerbert Irving Comprehensive Cancer Center
Funding
Exploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0MTraining in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7MStructure-function analysis for elucidating pathogenicity of cardiac ryanodine receptor genetic variantsR01HL145473 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, SHEPARD, KENNETH L · 2019 to 2022
$3.1MLIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomesR01AG070194 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LADNER, DANIELA P, MEHROTRA, SANJAY · 2021 to 2025
$3.1MRyanodine Receptor Defects in Cardiomyopathy Caused by Lamin A/C Gene MutationsR01HL142903 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, WORMAN, HOWARD J · 2019 to 2022
$1.8MCalcium and the physiology of diabetesR01DK118240 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2019 to 2022
$1.6MTraining in Cardiovascular Sciences for Under Represented StudentsR25HL156002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2021 to 2025
$624kCalcium and the Pathophysiology of Neurodegenerative DisordersR01NS114570 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2024 to 2024
$571kNHLBI NIH HHS R01 HL140934NHLBI NIH HHS R01 HL142903NHLBI NIH HHS R01 HL145473NHLBI NIH HHS R25 HL156002NHLBI NIH HHS T32 HL120826NIA NIH HHS R01 AG070194NIDDK NIH HHS R01 DK118240NINDS NIH HHS R01 NS114570
Abstract
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role in CD in HF remains unclear. Here, we show in hippocampal neurons from individuals and mice with HF that the RyR2/intracellular Ca
Indexed as
Cognitive DysfunctionHeart FailureRyanodine Receptor Calcium Release ChannelAnimalsCalciumMicePhosphorylationQuality of LifeTransforming Growth FactorsCalciumryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelTransforming Growth Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.