ArticleNature communications2023
Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- EgSPE, a secreted protein from Epichloë gansuensis, modulates symbiotic establishment and host drought tolerance.BMC plant biology · 2026Article
- From hidden allies to precision symbionts: unleashing endophytes for sustainable agroecosystems.World journal of microbiology & biotechnology · 2026Review
- NeuroViOme: a viral orfeome collection for studies of neurodegenerative disease.Journal of neurovirology · 2026Review
- Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation.Nature microbiology · 2026Article
- Effects of symbiotic bacteria on the parasitism efficacy ofFrontiers in microbiology · 2026Article
- Genome-Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms-Fish Hosts System and Drug Target Identification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Copalyl diphosphate synthase gene TaCPS1 mediated resistance to Fusarium graminearum in wheat in response to Piriformospora indica colonization.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Special Issue "Molecular Biology of Host and Pathogen Interactions: 2nd Edition".International journal of molecular sciences · 2025Article
- Unraveling the Intricacies of Powdery Mildew: Insights into Colonization, Plant Defense Mechanisms, and Future Strategies.International journal of molecular sciences · 2025Review
- A pipeline for validation of Serendipita indica effector-like sRNA suggests cross-kingdom communication in the symbiosis with Arabidopsis.Journal of experimental botany · 2025Article
- Decoding Plant-Pathogen Interactions: A Comprehensive Exploration of Effector-Plant Transcription Factor Dynamics.Molecular plant pathology · 2025Review
- Ammonia leakage can underpin nitrogen-sharing among soil microorganisms.The ISME journal · 2024Article
- Accelerating protein-protein interaction screens with reduced AlphaFold-Multimer sampling.Bioinformatics advances · 2024Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have benefited from interactions with symbionts for coping with challenging environments since the colonisation of land. The mechanisms of symbiont-mediated beneficial effects and similarities and differences to pathogen strategies are mostly unknown. Here, we use 106 (effector-) proteins, secreted by the symbiont Serendipita indica (Si) to modulate host physiology, to map interactions with Arabidopsis thaliana host proteins. Using integrative network analysis, we show significant convergence on target-proteins shared with pathogens and exclusive targeting of Arabidopsis proteins in the phytohormone signalling network. Functional in planta screening and phenotyping of Si effectors and interacting proteins reveals previously unknown hormone functions of Arabidopsis proteins and direct beneficial activities mediated by effectors in Arabidopsis. Thus, symbionts and pathogens target a shared molecular microbe-host interface. At the same time Si effectors specifically target the plant hormone network and constitute a powerful resource for elucidating the signalling network function and boosting plant productivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.