SynthesisNature communications2023
Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 6 pooled it
34.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 6 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
- Multi-ancestry genetic architecture of heart failure subtypes.Nature communications · 2026Pooled it
- Genomic data-driven framework for drug target discovery in atrial fibrillation.Journal of translational medicine · 2025Pooled it
- Genome-wide analysis identifies susceptibility loci for heart failure and nonischemic cardiomyopathy subtype in the East Asian populations.PLoS genetics · 2025Pooled it
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- Genetic insights into cardiac conduction disorders from genome-wide association studies.Human genomics · 2025Pooled it
- Integrating multi-omics and mendelian randomization identifies therapeutic targets for Lichen Sclerosus: A druggable genome-wide study.Global medical genetics · 2026Article
- Integrative genomic and proteomic analyses identify candidate genetic loci and genetically supported proteins in age-related macular degeneration.Eye and vision (London, England) · 2026Article
- Advancing PCOS drug development: multi-omics discovery of key targets and repurposable compounds.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Systematic Identification of Therapeutic Targets and Repurposed Drugs for Stroke: From Genome Causal Analysis to Multilevel Validation.Journal of the American Heart Association · 2026Article
- Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Schizophrenia.Schizophrenia bulletin · 2026Article
- LocusPackRat: an R package to support prioritizing candidate genes from large GWAS intervals with standardized evidence aggregation.G3 (Bethesda, Md.) · 2026Article
- Integrative omics analysis incorporating cardiovascular magnetic resonance imaging pinpoints potentially druggable plasma proteins for cardiovascular diseases.Life metabolism · 2026Article
- Molecular Mechanisms and Multi-Omics Integration in Heart Failure: From Pathophysiology to Precision Medicine.International journal of molecular sciences · 2026Review
- Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism.EMBO molecular medicine · 2026Article
- Decoding the Heart Failure Peptidome.Circulation. Heart failure · 2026Article
- Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art.Genetic epidemiology · 2026Review
- Rare coding and noncoding variants map 1,342 diseases and biomarkers in 490,549 whole genomes.medRxiv : the preprint server for health sciences · 2026Article
- Integrative mendelian randomization approaches for therapeutic target prioritisation in immune-mediated diseases.Scientific reports · 2026Article
- Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure.Nature communications · 2026Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 16 institutions in 5 countries.
Danielle Rasooly *Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA. drasooly@bwh.harvard.edu.ORCID 0000-0001-7715-1809
Gina M Peloso *Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.ORCID 0000-0002-5355-8636
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, Av Dr Eneas de Carvalho Aguiar 54, São Paulo, 5403000, Brazil.
Hesam DashtiDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.
Claudia GiambartolomeiHealth Data Science Centre, Human Technopole, V.le Rita Levi-Montalcini, 1, Milan, 20157, Italy.ORCID 0000-0003-2786-1225
Eleanor WheelerMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.ORCID 0000-0002-8616-6444
Nay AungWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.ORCID 0000-0001-5095-1611
Brian R FerolitoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
Maik PietznerMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.ORCID 0000-0003-3437-9963
Eric H Farber-EgerVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-0281-3796
Quinn Stanton WellsVanderbilt University Med. Ctr., Departments of Medicine (Cardiology), Biomedical Informatics, and Pharmacology, Nashville, TN, USA.
Nicole M KosikMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.ORCID 0000-0003-1384-7035
Liam GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
Daniel C PosnerMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
A Patrícia BentoDepartment of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
Qin HuiDepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.
Chang LiuDepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.ORCID 0000-0002-8918-7224
Krishna AragamMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.ORCID 0000-0003-3223-9131
Zeyuan WangDepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.
Brian CharestMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
Jennifer E HuffmanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.ORCID 0000-0002-9672-2491
Peter W F WilsonAtlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.
Lawrence S PhillipsAtlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.
John WhittakerMRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, United Kingdom.ORCID 0000-0002-3529-2379
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.ORCID 0000-0002-4176-2947
Steffen E PetersenBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK.ORCID 0000-0003-4622-5160
Kelly ChoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.
Andrew R LeachDepartment of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.ORCID 0000-0001-8178-0253
María Paula MagariñosDepartment of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
John Michael GazianoDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.
VA Million Veteran Program
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.
Yan V SunDepartment of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.ORCID 0000-0002-2838-1824
Jacob JosephCardiology Section, VA Providence Healthcare System, 830 Chalkstone Avenue, Providence, RI, 02908, USA. jacob.joseph@va.gov.
Juan P CasasDivision of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.
Emory University · USVA Boston Healthcare System · USBrigham and Women's Hospital · USEuropean Bioinformatics Institute · GBUniversity of Cambridge · GBBroad Institute · USQueen Mary University of London · GBSt Bartholomew's Hospital · GBBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEBoston University · USBrown University · USHarvard University · USItalian Institute of Technology · ITVanderbilt University · USVanderbilt University Medical Center · USWoodruff Health Sciences Center · US
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MCHANGING THE NATURAL HISTORY OF TYPE 2 DIABETES – “CHANGE” STUDYR01DK127083 · NIDDK · EMORY UNIVERSITY · PI PHILLIPS, LAWRENCE S · 2021 to 2025
$1.7MAssessing Barriers and Facilitators for Participating Structured Lifestyle Intervention and its Real-world Effectiveness and Cost-Effectiveness among US VeteransU18DP006711 · DP · UNIVERSITY OF FLORIDA · PI PHILLIPS, LAWRENCE S, SHAO, HUI · 2022 to 2022
$570kThe Role of Tuberculosis Disease on Non-Communicable Disease Risk: Comparative Analysis of Large Healthcare DatabasesR21AI156161 · NIAID · EMORY UNIVERSITY · PI CRITCHLEY, JULIA ALISON, MAGEE, MATTHEW JAMES · 2021 to 2022
$372kDiabetic Complications and Genetic Variants in the Million Veterans ProgramI01CX001737 · VA · VETERANS HEALTH ADMINISTRATION · PI PHILLIPS, LAWRENCE S · 2019 to 2023
–Cardiovascular Disease Risk Factors, Cardiovascular Disease Risk Prediction, and Genetics in the Million Veteran ProgramI01BX004821 · VA · VETERANS HEALTH ADMINISTRATION · PI PETER WYMAN WILSON · 2020 to 2026
–Prediction of CVD Risk in VeteransI01CX001025 · VA · VETERANS HEALTH ADMINISTRATION · PI CHO, KELLY, WILSON, PETER WYMAN · 2014 to 2025
–Diabetic Complications and Genetic Variants in the Million Veterans ProgramI01BX005831 · VA · VETERANS HEALTH ADMINISTRATION · PI PHILLIPS, LAWRENCE S, SUN, YAN · 2022 to 2025
–ACL HHS U18DP006711BLRD VA I01 BX004821BLRD VA I01 BX005831CSRD VA I01 CX001025CSRD VA I01 CX001737Department of Health NIHR203330Medical Research Council MC_PC_13046Medical Research Council MC_UU_00002/18Medical Research Council MC_UU_12015/1NCATS NIH HHS UL1 TR002378NCCDPHP CDC HHS U18 DP006711NHGRI NIH HHS T32 HG002295NIAID NIH HHS R21 AI156161NIDDK NIH HHS R01 DK127083
Abstract
We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinants for heart failure. Using the GWAS results and blood protein quantitative loci, we perform Mendelian randomization and colocalization analyses on human proteins to provide putative causal evidence for the role of druggable proteins in the genesis of heart failure. We identify 39 genome-wide significant heart failure risk variants, of which 18 are previously unreported. Using a combination of Mendelian randomization proteomics and genetic cis-only colocalization analyses, we identify 10 additional putatively causal genes for heart failure. Findings from GWAS and Mendelian randomization-proteomics identify seven (CAMK2D, PRKD1, PRKD3, MAPK3, TNFSF12, APOC3 and NAE1) proteins as potential targets for interventions to be used in primary prevention of heart failure.
Indexed as
Genome-Wide Association StudyHeart FailureHumansMendelian Randomization AnalysisProteomics
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