ArticleCerebral cortex (New York, N.Y. : 1991)2023
Insula-cingulate structural and functional connectivity: an ultra-high field MRI study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Orbitozygomatic-transsylvian approach to the insula: microsurgical anatomy and endoscopic correlation using the fiber-separation technique.Langenbeck's archives of surgery · 2026Article
- Orofacial Central Pattern Generators: Neuroanatomical and Clinical Insights into Sensory, Motor, Emotional Integration.Experimental neurobiology · 2026Review
- The human claustrum supports cognitive networks for externally and internally driven task demands.PLoS biology · 2026Article
- Impairment of the GABAergic system in the prefrontal cortex of male heroin addicts.European archives of psychiatry and clinical neuroscience · 2026Article
- Central autonomic network dysfunction in Stroke-Heart Syndrome: mechanistic roles of the insula and limbic system.Frontiers in neuroscience · 2026Review
- Napping restores working memory and brain activation impaired by sleep deprivation.IBRO neuroscience reports · 2025Article
- Impairment of the GABAergic system in the anterior midcingulate cortex of heroin-addicted males.European archives of psychiatry and clinical neuroscience · 2025Article
- Study of pain perception under negative emotions and its large-scale brain network dynamics in adolescents with non-suicidal self-injury.Frontiers in psychiatry · 2025Article
- Delineation of the trigeminal-lateral parabrachial-central amygdala tract in humans.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sensory driven neurophysiological mechanisms of concussion: a parsimonious and falsifiable theory.Frontiers in neurology · 2025Article
- Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Anatomo-functional basis of emotional and motor resonance elicited by facial expressions.Brain : a journal of neurology · 2024Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.Current biology : CB · 2024Article
- Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study.bioRxiv : the preprint server for biology · 2024Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The insula and the cingulate are key brain regions with many heterogenous functions. Both regions are consistently shown to play integral roles in the processing of affective, cognitive, and interoceptive stimuli. The anterior insula (aINS) and the anterior mid-cingulate cortex (aMCC) are two key hubs of the salience network (SN). Beyond the aINS and aMCC, previous 3 Tesla (T) magnetic resonance imaging studies have suggested both structural connectivity (SC) and functional connectivity (FC) between other insular and cingulate subregions. Here, we investigate the SC and FC between insula and cingulate subregions using ultra-high field 7T diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI). DTI revealed strong SC between posterior INS (pINS) and posterior MCC (pMCC), and rs-fMRI revealed strong FC between the aINS and aMCC that was not supported by SC, indicating the likelihood of a mediating structure. Finally, the insular pole had the strongest SC to all cingulate subregions, with a slight preference for the pMCC, indicative of a potential relay node of the insula. Together these finding shed new light on the understanding of insula-cingulate functioning, both within the SN and other cortical processes, through a lens of its SC and FC.
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