Evidence map›Paper›PMID 37429676›Full record

ArticleBMJ open2023

An open-label pilot trial of faecal microbiome transfer to restore the gut microbiome in anorexia nervosa: protocol.

Brooke C Wilson, José G B Derraik, Benjamin B Albert, Karen S W Leong, Ry Y Tweedie-Cullen, Christine Creagh, Marysia Depczynski, Taygen Edwards, Tommi Vatanen, Hiran Thabrew and 2 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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  3. Review
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  5. Review
  6. Article
  7. The current clinical approach to feeding and eating disorders aimed to increase personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Brooke C WilsonLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-2213-542X
José G B DerraikLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-1226-1956
Benjamin B AlbertLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0498-3473
Karen S W LeongLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-5733-8665
Ry Y Tweedie-CullenLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0128-7181
Christine CreaghLiggins Institute, The University of Auckland, Auckland, New Zealand.
Marysia DepczynskiLiggins Institute, The University of Auckland, Auckland, New Zealand.
Taygen EdwardsLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0001-7619-0398
Tommi VatanenLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0949-1291
Hiran ThabrewDepartment of Psychological Medicine, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8755-6217
Wayne S CutfieldLiggins Institute, The University of Auckland, Auckland, New Zealand.ORCID 0000-0001-6107-3682
Justin M O'SullivanLiggins Institute, The University of Auckland, Auckland, New Zealand justin.osullivan@auckland.ac.nz.ORCID 0000-0003-2927-450X
University of Auckland · NZUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIndividuals with anorexia nervosa (AN) harbour distinct gut microbiomes compared with healthy individuals, which are sufficient to induce weight loss and anxiety-like behaviours when transplanted into germ-free mice. We hypothesise that faecal microbiome transfer (FMT) from healthy donors would help restore the gut microbiome of individuals with AN, which in turn, may aid patient recovery.

methodsWe aim to conduct an open-label pilot study in 20 females aged 16-32 years in Auckland, New Zealand who meet the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria for AN and have a body mass index 13-19 kg/m ETHICS AND DISSEMINATION: Ethics approval was provided by the Central Health and Disability Ethics Committee (Ministry of Health, New Zealand, 21/CEN/212). Results will be published in peer-reviewed journals and presented to both scientific and consumer group audiences. TRIAL REGISTRATION NUMBER: ACTRN12621001504808.

Indexed as

Anorexia NervosaGastrointestinal MicrobiomeMicrobiotaAdolescentAdultCapsulesFemaleHumansPilot ProjectsYoung AdultCapsuleseating disordersgastroenterologymicrobiologytherapeuticstransplant medicine

Identifiers

PMID37429676
PMCPMC10335415
OpenAlexW4383873177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.