SynthesisBMJ paediatrics open2023
Congenital anomalies and risk factors in Africa: a systematic review and meta-analysis.
Synthesis in BMJ paediatrics open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Prevalence and associated factors of congenital anomalies in Ethiopia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort.BMC medical genomics · 2026Article
- Patterns and risk factors of birth defects in Bangladesh: evidence from a neonatal intensive care unit.BMC pregnancy and childbirth · 2026Observational
- Preserving paleoteratological history: a study of congenital anomalies from Vilnius University's medical collection.Forensic science, medicine, and pathology · 2026Article
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- Article
- Human-Centered Design of a Contextualized Service Delivery Model for Families of Infants With Major Congenital Anomalies in Kenya.Birth defects research · 2026Article
- A Population-Based Study of U.S. Trends in Selected Congenital Anomalies (2016-2023) and Socio-Demographic Disparities: A CDC WONDER Analysis.Children (Basel, Switzerland) · 2026Article
- Determinants of congenital anomalies among newborns in public hospitals of Northern Ethiopia: case-control study design.Scientific reports · 2026Article
- Newborn examination practices and congenital anomaly detection in public health facilities in Addis Ababa, Ethiopia: a qualitative exploratory study.Frontiers in pediatrics · 2026Article
- Congenital anomalies of the kidney and urinary tract in children treated at a tertiary hospital in Northern Tanzania: assessment of coexisting congenital anomalies.World journal of pediatric surgery · 2026Article
- Whole Exome Sequencing Uncovers Genetic Syndromes Associated with Orofacial Clefts presenting with Limb abnormalities in a Sub-Saharan African cohort.Research square · 2025Article
- Anterior abdominal wall agenesis associated with cardiac exstrophy and macrocephaly in a gold mining area of the Democratic Republic of the Congo: management and prognosis in a resource-limited area.Maternal health, neonatology and perinatology · 2025Article
- Prevalence of Congenital Anomalies and Its Associated Factors Among Newborns in Central Ethiopia Region Public Hospitals, Ethiopia: A Retrospective Cross-Sectional Study, 2023.Public health challenges · 2025Article
- Patterns and Associated Factors of Congenital Anomalies Among Neonates in 14 Yemeni Governorates 2021-2023: A Case: Control Study.Global epidemiology · 2025Article
- Impact of Reducing Time Lived With Colostomies on Social Stigma Affecting Children With Anorectal Malformations in Southwestern Uganda.World journal of surgery · 2025Article
- Spectrum of congenital anomalies detected through anatomy ultrasound at a referral hospital in Ghana.BMC pregnancy and childbirth · 2025Article
- Prevalence of Congenital Anomalies Among Pregnant Women at a Tertiary Care Center: A Cross-Sectional study.Cureus · 2025Article
- Article
- Clinical Diagnosis and Management Challenges of Harlequin Ichthyosis in a Preterm Neonate: A Case Report From Uganda.Case reports in dermatological medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the pooled prevalence and identify risk factors of congenital anomalies among neonates in Africa.
methodsThe pooled birth prevalence of congenital anomalies was the first outcome of this review, and the pooled measure of association between congenital anomalies and related risk factors in Africa was the second. We conducted a thorough search of the databases PubMed/ Medline, PubMed Central, Hinary, Google, Cochrane Library, African Journals Online, Web of Science and Google Scholar up to 31 January 2023. The JBI appraisal checklist was used to evaluate the studies. STATA V.17 was used for the analysis. The I
resultThis systematic review and meta-analysis includes 32 studies with a total of 626 983 participants. The pooled prevalence of congenital anomalies was 23.5 (95% CI 20 to 26.9) per 1000 newborns. Not taking folic acid (pooled OR=2.67; 95% CI (1.42 to 5.00)), history of maternal illness (pooled OR=2.44, 95% CI (1.2 to 4.94)), history of drug use (pooled OR=2.74, 95% CI (1.29 to 5.81)), maternal age (>35 years.) (Pooled OR=1.97, 95% CI (1.15 to 3.37)), drinking alcohol (pooled OR=3.15, 95% CI (1.4 to 7.04)), kchat chewing (pooled OR=3.34, 5% CI (1.68 to 6.65)) and urban residence (pooled OR=0.58, 95% CI (0.36 to 0.95)) were had significant association with congenital anomalies.
conclusionThe pooled prevalence of congenital abnormalities in Africa was found to be substantial, with significant regional variation. Appropriate folate supplementation during pregnancy, proper management of maternal sickness, proper antenatal care, referring healthcare personnel before using drugs, avoiding alcohol intake and kchat chewing are all important in lowering the occurrence of congenital abnormalities among newborns in Africa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.