ArticleGastroenterology2023
Serum 25-Hydroxyvitamin D Levels and Risk of Colorectal Cancer: An Age-Stratified Analysis.
Article in Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between vitamin D status and thyroid cancer: a meta-analysis.Frontiers in nutrition · 2024Pooled it
- Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults.Microbiology spectrum · 2024Trial
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review.Cancers · 2026Review
- Association Between Serum Vitamin D Levels and Colorectal Carcinoma: Insights from a Case Control Study in Northern Saudi Arabia.Life (Basel, Switzerland) · 2026Article
- KDM6A alternative splicing induced by 25(OH)D inhibits breast cancer cell stemness through repressing TRAP1 transcription.Oncogene · 2026Article
- The causal associations of 25(OH)D and its metabolites with oropharyngeal cancer risk: a Mendelian randomization study.Acta odontologica Scandinavica · 2025Article
- Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.Nutrition journal · 2025Article
- Serum 25(OH)D Levels and Risk of Nonalcoholic Fatty Liver Disease in Nonobese and Lean Individuals.Yonsei medical journal · 2025Article
- Association between serum 25-hydroxyvitamin D concentration and the risk of colorectal cancer: A cross-sectional study.PloS one · 2025Article
- Serum 25 (OH) D levels and risk of female-specific cancer in premenopausal women: a prospective study.Frontiers in nutrition · 2025Article
- Factors Affecting Cancer Mortality in Young Adults: Findings from a Prospective Cohort Study.Cancers · 2024Article
- Vitamin D in Cancer Prevention and Treatment: A Review of Epidemiological, Preclinical, and Cellular Studies.Cancers · 2024Review
- Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility.International journal of molecular sciences · 2024Article
- Adiposity, Body Composition Measures, and Breast Cancer Risk in Korean Premenopausal Women.JAMA network open · 2024Article
- Early-onset gastrointestinal cancer: An epidemiological reality with great significance and implications.World journal of gastrointestinal oncology · 2024Article
- Clinical data mining: challenges, opportunities, and recommendations for translational applications.Journal of translational medicine · 2024Review
- Vitamin D and Early-Onset Colorectal Cancer-Rays of Hope?Gastroenterology · 2023Article
- Early-onset colorectal cancer in patients younger than 50 years: a systematic review of the literature.Annals of gastroenterologyReview
- Cancer statistics for African American and Black people, 2025.CA: a cancer journal for cliniciansArticle
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsThe role of circulating 25-hydroxyvitamin D (25(OH)D) in the prevention of early-onset colorectal cancer (CRC) in young adults aged <50 years is uncertain. We evaluated the age-stratified associations (<50 vs ≥50 years) between circulating 25(OH)D levels and the risk of CRC in a large sample of Korean adults.
methodsOur cohort study included 236,382 participants (mean age, 38.0 [standard deviation, 9.0] years) who underwent a comprehensive health examination, including measurement of serum 25(OH)D levels. Serum 25(OH)D levels were categorized as <10, 10 to 20, and ≥20 ng/mL. CRC, along with the histologic subtype, site, and invasiveness, was ascertained through linkage with the national cancer registry. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CRC according to the serum 25(OH)D status, with adjustment for potential confounders.
resultsDuring the 1,393,741 person-years of follow-up (median, 6.5 years; interquartile range, 4.5-7.5 years), 341 participants developed CRC (incidence rate, 19.2 per 10
conclusionsSerum 25(OH)D levels may have beneficial associations with the risk of developing CRC for both early-onset and late-onset disease.
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