Evidence map›Paper›PMID 37429225›Full record

ArticlePediatric neurology2023

Neonatal Botulism: A Case Series Suggesting Varied Presentations.

David E Horvat, Philip G Eye, Mathew T Whitehead, Diana Bharucha-Goebel, Emmeline Roth, Tayyba Anwar, Tammy Tsuchida, Youssef A Kousa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. That head lag is impressive! Infantile botulism in the NICU: a case report.Maternal health, neonatology and perinatology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

David E HorvatDepartment of Neurology, Walter Reed National Military Medical Center, Bethesda, Maryland.
Philip G EyeDepartment of Pediatrics, Tripler Army Medical Center, Honolulu, Hawaii.
Mathew T WhiteheadDivision of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Diana Bharucha-GoebelNeuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disroders and Stroke, National Institutes of Health, Bethesda, Maryland; Division of Neurology, Children's National Hospital, Washington, District of Columbia; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Emmeline RothDivision of Neurology, Children's National Hospital, Washington, District of Columbia; Neonatal Neurology Program, Children's National Hospital, Washington, District of Columbia.
Tayyba AnwarDivision of Neurology, Children's National Hospital, Washington, District of Columbia; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Neonatal Neurology Program, Children's National Hospital, Washington, District of Columbia; Division of Neurophysiology, Epilepsy, and Critical Care, Children's National Hospital, Washington, District of Columbia; Department of Genomics and Precision Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Tammy TsuchidaDivision of Neurology, Children's National Hospital, Washington, District of Columbia; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Neonatal Neurology Program, Children's National Hospital, Washington, District of Columbia; Division of Neurophysiology, Epilepsy, and Critical Care, Children's National Hospital, Washington, District of Columbia; Department of Genomics and Precision Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Youssef A KousaDivision of Neurology, Children's National Hospital, Washington, District of Columbia; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Neurology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Neonatal Neurology Program, Children's National Hospital, Washington, District of Columbia; Division of Neurophysiology, Epilepsy, and Critical Care, Children's National Hospital, Washington, District of Columbia; Department of Genomics and Precision Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia. Electronic address: ykousa@childrensnational.org.
George Washington University Hospital · USChildren's Hospital of Philadelphia · USChildren's National · USNational Institutes of Health · USTripler Army Medical Center · USWalter Reed National Military Medical Center · US

Funding

Viral Neurobiology in the Prenatal BrainK08NS119882 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI Youssef A Kousa · 2022 to 2026
$1.1M
NICHD NIH HHS L40 HD102847NINDS NIH HHS K08 NS119882
6 · The paper itself

Abstract

Infantile botulism is an uncommon diagnosis and rarer still in the neonatal period. We describe three cases of neonatal-onset botulism that presented with symptoms typically (hypotonia, constipation, facial diplegia) or atypically seen in older infants (encephalopathy, seizures, and hypothermia). Our series shows a wider spectrum of clinical presentations in patients with neonatal-onset botulism. Our report also suggests that neonatal-onset botulism should be considered more broadly in the hypotonic infant, especially as the condition is treatable with intravenous botulinum-specific immune globulin.

Indexed as

BotulismClostridium botulinumInfant, Newborn, DiseasesAgedAntibodiesHumansImmunoglobulins, IntravenousInfantInfant, NewbornAntibodiesImmunoglobulins, IntravenousBotulinum toxinBotulismNeonatalNeuromuscularRespiratory distress

Identifiers

PMID37429225
PMCPMC10527512
OpenAlexW4380742140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.