ArticleProceedings of the National Academy of Sciences of the United States of America2023
Metallacage-based enhanced PDT strategy for bacterial elimination via inhibiting endogenous NO production.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- A general strategy for high-efficiency live bacteria imaging and targeted phototherapy.Chemical science · 2026Article
- Alginate lyase immobilizedActa pharmaceutica Sinica. B · 2025Article
- Interfering with proton and electron transfer enables antibacterial starvation therapy.Science advances · 2025Article
- Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria.Future medicinal chemistry · 2025Review
- Potential of Resveratrol to Combine with Hydrogel for Photodynamic Therapy against Bacteria and Cancer-A Review.Biomedicines · 2024Review
- Self-Assembled Nanocomposite DOX/TPORPharmaceutics · 2024Article
- Supramolecular coordination platinum metallacycle-based multilevel wound dressing for bacteria sensing and wound healing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Bee-saving symbionts.Nature reviews. Microbiology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics are among the most used weapons in fighting microbial infections and have greatly improved the quality of human life. However, bacteria can eventually evolve to exhibit antibiotic resistance to almost all prescribed antibiotic drugs. Photodynamic therapy (PDT) develops little antibiotic resistance and has become a promising strategy in fighting bacterial infection. To augment the killing effect of PDT, the conventional strategy is introducing excess ROS in various ways, such as applying high light doses, high photosensitizer concentrations, and exogenous oxygen. In this study, we report a metallacage-based PDT strategy that minimizes the use of ROS by jointly using gallium-metal organic framework rods to inhibit the production of bacterial endogenous NO, amplify ROS stress, and enhance the killing effect. The augmented bactericidal effect was demonstrated both in vitro and in vivo. This proposed enhanced PDT strategy will provide a new option for bacterial ablation.
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