Evidence map›Paper›PMID 37428831›Full record

ArticleCirculation2023

Myocardial Neprilysin Is Increased in Hypertrophic Cardiomyopathy.

David W J Armstrong, Lance A Riley, Yan Ru Su, Ashish S Shah, Tarek Absi, Deepak K Gupta, Quinn S Wells, D Marshall Brinkley, Lynne W Stevenson, W David Merryman

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David W J ArmstrongFrom the Division of Cardiovascular Medicine (D.W.J.A., Y.R.S., D.K.G., Q.S.W., D.M.B., L.W.S.), Vanderbilt University, Nashville, TN.ORCID 0000-0003-3198-7277
Lance A RileyDepartments of Biomedical Engineering (L.A.R., W.D.M.), Vanderbilt University, Nashville, TN.
Yan Ru SuFrom the Division of Cardiovascular Medicine (D.W.J.A., Y.R.S., D.K.G., Q.S.W., D.M.B., L.W.S.), Vanderbilt University, Nashville, TN.
Ashish S ShahCardiac Surgery (A.S.S., T.A.), Vanderbilt University, Nashville, TN.
Tarek AbsiCardiac Surgery (A.S.S., T.A.), Vanderbilt University, Nashville, TN.
Deepak K GuptaFrom the Division of Cardiovascular Medicine (D.W.J.A., Y.R.S., D.K.G., Q.S.W., D.M.B., L.W.S.), Vanderbilt University, Nashville, TN.ORCID 0000-0003-2191-3485
Quinn S WellsFrom the Division of Cardiovascular Medicine (D.W.J.A., Y.R.S., D.K.G., Q.S.W., D.M.B., L.W.S.), Vanderbilt University, Nashville, TN.ORCID 0000-0003-3899-0313
D Marshall BrinkleyFrom the Division of Cardiovascular Medicine (D.W.J.A., Y.R.S., D.K.G., Q.S.W., D.M.B., L.W.S.), Vanderbilt University, Nashville, TN.ORCID 0000-0002-9511-7767
Lynne W StevensonFrom the Division of Cardiovascular Medicine (D.W.J.A., Y.R.S., D.K.G., Q.S.W., D.M.B., L.W.S.), Vanderbilt University, Nashville, TN.ORCID 0000-0002-8626-5258
W David MerrymanDepartments of Biomedical Engineering (L.A.R., W.D.M.), Vanderbilt University, Nashville, TN.ORCID 0000-0001-9662-1503
Vanderbilt University · US

Funding

Mechanobiology of Cardiopulmonary FibrosisR35HL135790 · NHLBI · VANDERBILT UNIVERSITY · PI MERRYMAN, WILLIAM D · 2017 to 2023
$5.5M
Innovative natriuretic peptide-based therapy for hypertrophic cardiomyopathyF32HL165917 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARMSTRONG, DAVID WILLIAM JOHN · 2022 to 2023
$166k
NHLBI NIH HHS F32 HL165917NHLBI NIH HHS R35 HL135790
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiomyopathy, HypertrophicNeprilysinHumansMyocardiumNeprilysincardiomyopathy, hypertrophicheart failureneprilysin

Identifiers

PMID37428831
PMCPMC10348475
OpenAlexW4383756870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.