Evidence map›Paper›PMID 37428632›Full record

ArticleCell reports2023

Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.

Sehyoun Yoon, Marc Dos Santos, Marc P Forrest, Christopher P Pratt, Natalia Khalatyan, Peter J Mohler, Jeffrey N Savas, Peter Penzes

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Longitudinal Characterization of GiantResearch (Washington, D.C.) · 2026
    Article
  4. Cytoskeletal scaffolding of NaCurrent opinion in cell biology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sehyoun YoonDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Marc Dos SantosDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Marc P ForrestDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Christopher P PrattDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Natalia KhalatyanDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Peter J MohlerDepartments of Internal Medicine and Physiology, Dorothy M. Davis Heart and Lung Research Institute, Frick Center for Heart Failure and Arrhythmia Research; Ohio State University College of Medicine, Columbus, OH 43210, USA.
Jeffrey N SavasDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Peter PenzesDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Northwestern University, Center for Autism and Neurodevelopment, Chicago, IL 60611, USA. Electronic address: p-penzes@northwestern.edu.
Northwestern University · USLung Institute · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Postsynaptic roles of ankyrinsR01MH107182 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Peter Penzes · 2015 to 2026
$5.6M
NCI NIH HHS P30 CA060553NIMH NIH HHS R01 MH107182
6 · The paper itself

Abstract

Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory neurons and oligodendrocytes (Ank2

Indexed as

AnkyrinsProsencephalonProteomeSeizuresAnimalsCalciumMiceMice, KnockoutPhenotypeProteomicsAnk2 protein, mouseAnkyrinsCalciumProteomeankyrinanti-epileptic drugcalcium imagingCP: Developmental biologyCP: NeuroscienceLC-MS/MSpostsynaptic interactomeproteomicssynchrony

Identifiers

PMID37428632
PMCPMC10566302
OpenAlexW4383682990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.