Evidence map›Paper›PMID 37428312›Full record

ArticleParasitology research2023

Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis.

Carlos Alexandre Aguiar Moreira, Luis Henrique Vallesquino Murayama, Tatiane de Camargo Martins, Vinicius Tadeu Oliveira, Diego Generoso, Vania Maria de Vasconcelos Machado, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Rodrigo Bazan, Marco Antônio Zanini and 3 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Carlos Alexandre Aguiar MoreiraDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Luis Henrique Vallesquino MurayamaDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Tatiane de Camargo MartinsDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Vinicius Tadeu OliveiraDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Diego GenerosoDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Vania Maria de Vasconcelos MachadoSchool of Veterinary Medicine and Animal Sciences, UNESP - São Paulo State University, Botucatu, Brazil.
Sabrina Setembre BatahRibeirão Preto Medical School, USP - São Paulo University, Ribeirão Preto, Brazil.
Alexandre Todorovic FabroRibeirão Preto Medical School, USP - São Paulo University, Ribeirão Preto, Brazil.
Rodrigo BazanDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Marco Antônio ZaniniDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil.
Edda SciuttoInstitute of Biomedical Investigations, UNAM - National Autonomous University of Mexico, Mexico City, Mexico.
Agnès FleuryInstitute of Biomedical Investigations, UNAM - National Autonomous University of Mexico, Mexico City, Mexico.
Pedro Tadao Hamamoto FilhoDepartment of Neurology, Psychology and Psychiatry, Botucatu Medical School. UNESP - São Paulo State University, Distrito de Rubião Jr, s/n, CEP 18606-986, Botucatu, São Paulo, Brazil. pedro.hamamoto@unesp.br.
Universidade Estadual Paulista (Unesp) · BRUniversidad Nacional Autónoma de México · MXClinics Hospital of Ribeirão Preto · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurocysticercosis is a heterogeneous disease, and the patient's sex seems to play a role in this heterogeneity. Hosts' sexual dimorphism in cysticercosis has been largely explored in the murine model of intraperitoneal Taenia crassiceps cysticercosis. In this study, we investigated the sexual dimorphism of inflammatory responses in a rat model of extraparenchymal neurocysticercosis caused by T. crassiceps. T. crassiceps cysticerci were inoculated in the subarachnoid space of Wistar rats (25 females, 22 males). Ninety days later, the rats were euthanized for histologic, immunohistochemistry, and cytokines studies. Ten animals also underwent a 7-T magnetic resonance imaging (MRI). Female rats presented a higher concentration of immune cells in the arachnoid-brain interface, reactive astrogliosis in the periventricular region, in situ pro-inflammatory cytokine (interleukin [IL]-6) and anti-inflammatory cytokine (IL-10), and more intense hydrocephalus on MRI than males. Intracranial hypertension signals were not observed during the observational period. Overall, these results suggest sexual dimorphism in the intracranial inflammatory response that accompanied T. crassiceps extraparenchymal neurocysticercosis.

Indexed as

CysticercosisNeurocysticercosisTaeniaAnimalsCytokinesDisease Models, AnimalFemaleInterleukin-6MaleMiceMice, Inbred BALB CRatsRats, WistarSex CharacteristicsCytokinesInterleukin-6HydrocephalusInflammationNeurocysticercosisSex dimorphismTaenia crassiceps

Identifiers

PMID37428312
OpenAlexW4383710985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.