Evidence map›Paper›PMID 37428223›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Longitudinal changes of health-related quality of life in childhood chronic kidney disease.

Joann Carlson, Arlene C Gerson, Matthew B Matheson, Sharon Manne, Marc Lande, Lyndsay Harshman, Rebecca J Johnson, Shlomo Shinnar, Amy J Kogon, Bradley Warady and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00327860 recruitingnot on this map

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2003 to 2028Enrolled1,300ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Joann CarlsonRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Joann.Carlson@rutgers.edu.ORCID http://orcid.org/0000-0002-6193-8428
Arlene C GersonThe Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Matthew B MathesonJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sharon ManneRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Marc LandeUniversity of Rochester Medical Center, Rochester, NY, USA.
Lyndsay HarshmanStead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Rebecca J JohnsonChildren's Mercy Kansas City, UMKC School of Medicine, Kansas City, MO, USA.
Shlomo ShinnarMontefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Amy J KogonChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Bradley WaradyChildren's Mercy Kansas City, UMKC School of Medicine, Kansas City, MO, USA.
Susan FurthChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
Stephen HooperSchool of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Children's Hospital of Philadelphia · USChildren's Mercy Hospital · USJohns Hopkins University · USRutgers, The State University of New Jersey · USAlbert Einstein College of Medicine · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of Rochester Medical Center · US

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U24DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Derek K Ng · 2018 to 2026
$12.6M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Central Biochemistry Laboratory of the CKID ConsortiumU24DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2018 to 2022
$1.7M
NICHD NIH HHS P50 HD103556NICHD NIH HHS P50 HD105352NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U24 DK066116NIDDK NIH HHS U24 DK082194
6 · The paper itself

Abstract

backgroundFew longitudinal studies have evaluated the impact of chronic kidney disease (CKD) duration on health-related quality of life (HRQOL). The study's aim was to determine how HRQOL changes over time in childhood CKD.

methodsStudy participants were children in the chronic kidney disease in children (CKiD) cohort who completed the pediatric quality of life inventory (PedsQL) on three or more occasions over the course of two or more years. Generalized gamma (GG) mixed-effects models were applied to assess the effect of CKD duration on HRQOL while controlling for selected covariates.

resultsA total of 692 children (median age = 11.2) with a median of 8.3 years duration of CKD were evaluated. All subjects had a GFR greater than 15 ml/min/1.73 m

conclusionsLonger duration of the disease is associated with improved HRQOL on child self-report scales; however, parent-proxy results were less likely to demonstrate any significant change over time. This divergence could be due to greater optimism and accommodation of CKD in children. Clinicians can use these data to better understand the needs of pediatric CKD patients. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Quality of LifeRenal Insufficiency, ChronicChildEmotionsHumansLongitudinal StudiesParentsTime FactorsChronic kidney diseaseLongitudinalParent–child agreementPediatric nephrologyPsychosocialQuality of life

Identifiers

PMID37428223
PMCPMC10591962
OpenAlexW4383710333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.