Observational studyTranslational vision science & technology2023
High-Resolution Optical Coherence Tomography in Healthy Individuals Provides Resolution at the Cellular and Subcellular Levels.
Observational study in Translational vision science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Retinal biomarkers for early Alzheimer's detection: a systematic review of optical coherence tomography (OCT) findings.BMJ open ophthalmology · 2026Pooled it
- High-Resolution Optical Coherence Tomography Visualizes Posterior Vitreous Lamellar Architecture in Eyes With Chronic Central Serous Chorioretinopathy.Translational vision science & technology · 2026Article
- Ocular Component Growth From the Cornea to the Sclera in Non-Human Primate Emmetropization.Investigative ophthalmology & visual science · 2026Article
- Morphometric Analysis of Retinal Vessels Using High-Resolution OCT Technology in Healthy Subjects.Investigative ophthalmology & visual science · 2026Observational
- Macular Layer Thickness with Spectral-Domain and High-Resolution OCT.Ophthalmology science · 2026Article
- Advances in diagnosing and treating diabetic retinopathy.Nature reviews. Endocrinology · 2026Review
- Deep learning fusion of multi-channel imaging from polarization-sensitive optical coherence tomography.Biomedical optics express · 2026Article
- genotype-phenotype correlation in lattice corneal dystrophy: added diagnostic value of high-resolution OCT.Scientific reports · 2026Article
- Optical Coherence Tomography Biomarkers Predicting Progression to Atrophy in Non-Exudative Age-Related Macular Degeneration.Diagnostics (Basel, Switzerland) · 2026Review
- Macular thickness profile in an adult population using Spectralis spectral-domain optical coherence tomography.Scientific reports · 2026Article
- Real-Time High-Resolution OCT for Imaging Retinal and Choroidal Blood Flow.Investigative ophthalmology & visual science · 2026Article
- Ultra-high resolution OCT imaging reveals retinal layer degeneration in RD10 mice with comparison to commercial standard resolution OCT.Scientific reports · 2026Article
- Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology.Ophthalmology science · 2026Article
- Choroidal changes after antiVEGF in neovascular age-related macular degeneration with type 1 and 3 macular neovascularization.International ophthalmology · 2025Observational
- High-resolution optical coherence tomography in pathology of the vitreomacular interface.American journal of ophthalmology case reports · 2025Article
- Comparison of Retinal Thickness Measurements Using Optos Monaco and Heidelberg Spectralis OCT Across ETDRS Sectors in Normal Eyes.Tomography (Ann Arbor, Mich.) · 2025Article
- Retinal Morphology in Successfully Treated Macula-Off Retinal Detachment Based on Semiautomated Layer Quantification of High-Resolution Optical Coherence Tomography.Translational vision science & technology · 2025Observational
- Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Hyperreflective Retinal Foci (HRF): Definition and Role of an Invaluable OCT Sign.Journal of clinical medicine · 2025Article
- Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use.Translational vision science & technology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To assess the clinical resolution capacities of a novel high-resolution optical coherence tomography (High-Res OCT). Methods: Eight healthy volunteers were included in this observational study. Using the SPECTRALIS High-Res OCT device (Heidelberg Engineering, Heidelberg) macular b-scans were taken and compared with b-scans acquired with a SPECTRALIS HRA+OCT device (Heidelberg Engineering, Heidelberg). High-Res OCT scans were also compared with hematoxylin and eosin-stained sections from a human donor retina. Results: High-Res OCT allowed identification of several retinal structures at the cellular and subcellular levels, namely, cell nuclei of ganglion cells, displaced amacrine cells, cone photoreceptors and retinal pigment epithelial cells compared with the commercial device. Rod photoreceptor nuclei were partially detectable. Localization of cell type-specific nuclei were confirmed by histological sections of human donor retina. Additionally, all three plexus of the retinal vasculature could be visualized. Conclusions: SPECTRALIS High-Res OCT device provides improved resolution compared with the conventional SPECTRALIS HRA+OCT device and allows to identify structures at the cellular level, similar to histological sections. Translational Relevance: High-Res OCT shows improved visualization of retinal structures in healthy individuals and can be used to assess individual cells within the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.