Evidence map›Paper›PMID 37428103›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2023

Beyond Neoantigens: Antigens Derived from Tumor Drivers as Cancer Vaccine Targets.

Erika J Crosby, Zachary C Hartman, H Kim Lyerly

Open access · hybridAbstract readComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Erika J CrosbyDepartment of Surgery, Duke University, Durham, North Carolina.ORCID 0000-0002-4872-6711
Zachary C HartmanDepartments of Surgery, Integrative Immunobiology, and Pathology, Duke University, Durham, North Carolina.ORCID 0000-0001-6549-8207
H Kim LyerlyDepartments of Surgery, Integrative Immunobiology, and Pathology, Duke University, Durham, North Carolina.ORCID 0000-0002-0063-4770
Duke University · US

Funding

Intratumoral immunotherapy to enhance T cell infiltration and augment immune checkpoint blockade responses across molecular subtypes of breast cancerK22CA262340 · NCI · DUKE UNIVERSITY · PI CROSBY, ERIKA J · 2022 to 2024
$396k
NCI NIH HHS K22 CA262340
6 · The paper itself

Abstract

A vaccine targeting HER2, a nonmutated but overexpressed tumor antigen, readily primed T cells for ex vivo expansion and adoptive transfer with minimal toxicity. This regimen led to intramolecular epitope spreading in a majority of patients and offers a treatment modality that may improve outcomes for patients with metastatic breast cancer expressing HER2. See related article by Disis et al., p. 3362.

Indexed as

Breast NeoplasmsCancer VaccinesAntigens, NeoplasmErb-b2 Receptor Tyrosine KinasesFemaleHumansT-LymphocytesAntigens, NeoplasmCancer VaccinesErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID37428103
PMCPMC10472089
OpenAlexW4383710663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.