Evidence map›Paper›PMID 37427864›Full record

ArticleIUBMB life2023

Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction-induced cardiomyopathy.

Jaime Balderas-Villalobos, J M Lourdes Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Janée Hayles, Rafael J Ramirez, Alex Y Tan, Karoly Kaszala, Montserrat Samsó, Jose F Huizar and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUBMB life, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jaime Balderas-VillalobosDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
J M Lourdes Medina-ContrerasDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Christopher LynchDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Rajiv KabadiPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Janée HaylesPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Rafael J RamirezDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Alex Y TanPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Karoly KaszalaPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Montserrat SamsóDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Jose F HuizarPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Jose M EltitDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0002-5288-1669
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0M
Mechanistic Insights of Premature Ventricular Contractions-induced CardiomyopathyR01HL139874 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HUIZAR, JOSE FRANCISCO · 2018 to 2020
$2.0M
RyR architecture and gatekeeping of internal calcium storesR01AR068431 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAMSO, MONTSERRAT · 2017 to 2021
$2.0M
Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine ModelI01BX004861 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI Jose Francisco Huizar · 2020 to 2026
–
American Heart Association-American Stroke Association 836430BLRD VA I01 BX004861NCI NIH HHS P30 CA016059NHLBI NIH HHS R01 HL139874NIAMS NIH HHS R01 AR068431
6 · The paper itself

Abstract

Frequent premature ventricular contractions (PVCs) promoted eccentric cardiac hypertrophy and reduced ejection fraction (EF) in a large animal model of PVC-induced cardiomyopathy (PVC-CM), but the molecular mechanisms and markers of this hypertrophic remodeling remain unexplored. Healthy mongrel canines were implanted with pacemakers to deliver bigeminal PVCs (50% burden with 200-220 ms coupling interval). After 12 weeks, left ventricular (LV) free wall samples were studied from PVC-CM and Sham groups. In addition to reduced LV ejection fraction (LVEF), the PVC-CM group showed larger cardiac myocytes without evident ultrastructural alterations compared to the Sham group. Biochemical markers of pathological hypertrophy, such as store-operated Ca

Indexed as

CardiomyopathiesVentricular Premature ComplexesAnimalsDisease Models, AnimalDogsHypertrophyVentricular Remodelingangiogenesiscardiac arrhythmiacompensatory hypertrophysignal transduction

Identifiers

PMID37427864
PMCPMC10592397
OpenAlexW4383709959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.